浆膜腔积液肿瘤标志物与血清肿瘤标志物及脱落细胞学检测结果的相关性分析

目的分析浆膜腔积液肿瘤标志物与血清肿瘤标志物及脱落细胞学检测结果的相关性。方法选取右江民族医学院附属医院2017年1月至2018年12月确诊的恶性肿瘤伴浆膜腔积液患者198例,均给予其脱落细胞学检查,并根据检测的结果划分为阳性组、阴性组,测定阳性组浆膜腔积液肿瘤标志物、血清肿瘤标志物水平,并对比分析两组浆膜腔积液肿瘤标志物检测结果。结果阳性组浆膜腔积液和血清中的癌胚抗原(CEA)、糖类抗原(CA)125、CA199、CA724、CA242、CA153、甲胎蛋白(AFP)水平具有一定相关性(P<0.05),其中,浆膜腔积液和血清中CEA的相关系数为0.734(P<0.05),CA125的相关系数为0.479(P<0.05),CA199的相关系数为0.749(P<0.05),CA724的相关系数为0.709(P<0.05),CA242的相关系数为0.881(P<0.05),CA153的相关系数为0.721(P<0.05),AFP的相关系数为0.456(P<0.05)。脱落细胞学阳性组中的胃癌患者CA724水平为48.64(27.80,287.22)U/mL,显著高于阴性组胃癌患者的20.45(9.78,87.16)U/mL,差异有统计学意义(P<0.05)。结论脱落细胞学阳性患者浆膜腔积液肿瘤标志物和血清肿瘤标志物之间具有一定相关性,而通过检测血清肿瘤标志物能够较好地反映出浆膜腔积液的肿瘤标志物水平;胃癌患者浆膜腔积液中的CA724可反映浆膜腔积液的良恶性。

Correlation analysis of serous cavity effusion tumor markers with serum tumor markers and results of exfoliative cytology

Objective To analyze the correlation between serous cavity effusion tumor markers with serum tumor markers and results of exfoliative cytology.Methods A total of 198 patients with malignant tumor with serous cavity effusion were selected from our hospital between January 2017 and December 2018.And the patients were given exfoliative cytology test,according to the result of detecting,the patients were divided into positive group and negative group.The serous cavity effusion tumor markers and serum tumor markers were detected in positive group at the same time,and the levels of serous cavity effusion tumor markers were compared between two groups.Results Serum carcinoembryonic antigen(CEA),carbohydrate antigen(CA)125,CA199,CA724,CA242,CA153 and Alpha fetoprotein(AFP)levels of malignant serosal effusion had some correlation with that of serum in positive group(P<0.05).The correlation coefficient of CEA in serous effusion and serum was 0.734(P<0.05),and which of CA125,CA199,CA724,CA242,CA153 and AFP were 0.479,0.749,0.709,0.881,0.721 and 0.456(P<0.05).CA724 level of in positive group of gastric cancer patients was 48.64(27.80,227.22)U/mL,which was higher than that in the negative group20.45(9.78,87.16)U/mL],and the difference was statistically significant(P<0.05).Conclusion There is a significant correlation between tumor markers of serous effusion and serum tumor markers in patients with positive results of exfoliative cytology,and the detection of serum tumor markers can better reflect the level of tumor markers of serous effusion.In addition,CA724 in ascites of gastric cancer can assist in the diagnosis of benign and malignant serous cavity effusion.