脑脊液及血清PCT、CD64、CRP在脑膜炎患儿中的鉴别诊断价值

目的探讨脑脊液及血清降钙素原(PCT)、CD64、C反应蛋白(CRP)在脑膜炎患儿中的鉴别诊断价值。方法以该院收治的120例急性脑膜炎患儿为研究对象,患儿在入院24 h及治疗7 d后,均接受腰椎穿刺检查。比较细菌性脑膜炎患儿和病毒性脑膜炎患儿脑脊液和血清中PCT、CD64、CRP水平。结果依据脑脊液、血清检测结果,120例患儿中细菌性脑膜炎55例(细菌性脑膜炎组),病毒性脑膜炎65例(病毒性脑膜炎组);入院后24 h内,细菌性脑膜炎组患儿脑脊液、血清PCT、CD64及CRP水平均明显高于病毒性脑膜炎组(P<0.05);治疗7 d后,两组患儿PCT、CD64及CRP水平比较差异无统计学意义(P>0.05)。结论脑脊液及血清PCT、CD64及CRP能够鉴别细菌性脑膜炎及病毒性脑膜炎,有助于指导临床合理用药及预后判断。

The differential value of serum and cerebrospinal fluid PCT,CD64 and CRP in infantile meningitis caused by different pathogens

Objective To investigate the differential value of cerebrospinal fluid and serum procalcitonin(PCT),CD64 and C-reactive protein(CRP)in infantile meningitis caused by different pathogens.Methods The clinical data of 120 children with acute meningitis admitted to our hospital in recent years were retrospectively analyzed.The 120 children underwent lumbar puncture examination within 24 h after admission and 7 d after treatment were selected.The levels of PCT,CD64 and CRP levels were detected cerebrospinal fluid and serum in bacterial meningitis and viral meningitis children.Results According to the results of cerebrospinal fluid and serum tests,there were 55 cases of bacterial meningitis children(bacterial meningitis group)and 65 cases of viral meningitis children(viral meningitis group).Within 24 h after admission,the levels of PCT,CD64 and CRP in cerebrospinal fluid and serum of children with bacterial meningitis group were significantly higher than that of the viral meningitis group(P<0.05).At 7 d after treatment,the levels of PCT,CD64 and CRP in cerebrospinal fluid and serum in the two groups were significantly lower than before treatment(P<0.05).There was no significant difference between the two groups(P>0.05).Conclusion Detecting of PCT,CD64 and CRP of cerebrospinal fluid and serum could distinguish bacterial meningitis from viral meningitis,which is helpful for clinical rational drug use and prognosis.