前列地尔联合疏血通治疗2型糖尿病肾病的疗效研究

目的探讨前列地尔联合疏血通治疗2型糖尿病肾病的疗效。方法选择2017年2月至2018年4月在该院诊治的2型糖尿病肾病患者128例为研究对象,随机分为研究组和对照组,每组各64例。对照组患者在常规治疗基础上应用前列地尔治疗,研究组在对照组治疗基础上应用疏血通治疗。分别于治疗前后检测两组24 h尿蛋白定量、尿素氮(BUN)、血肌酐(Scr)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、丙二醛(MDA)、超氧化物歧化酶(SOD)及血液流变学指标。结果两组治疗后24 h尿蛋白定量、BUN、Scr、全血黏度(低切、高切)、血浆黏度、红细胞聚集指数、CRP、TNF-α、MDA水平均较治疗前下降(P<0.05),SOD水平较治疗前升高(P<0.05);治疗后研究组24 h尿蛋白定量、BUN、Scr、全血黏度(低切、高切)、血浆黏度、红细胞聚集指数、CRP、TNF-α、MDA水平均低于对照组(P<0.05),SOD水平高于对照组(P<0.05)。结论前列地尔联合疏血通治疗2型糖尿病肾病疗效确切,能显著提高患者肾功能水平,降低血清炎症因子水平,改善患者体内的氧化应激状态和血液流变学,值得在临床推广应用。

Effect of Alprostadil combined with Shuxuetong on type 2 diabetic nephropathy

Objective To explore the effect of Alprostadil combined with Shuxuetong in the treatment of type 2 diabetic nephropathy.Methods A total of 128 patients with type 2 diabetic nephropathy diagnosed and treated at the hospital from February 2017 to April 2018 were selected as the research subjects,and randomly divided into study group and control group,each with 64 patients.The control group was treated with Alprostadil on the basis of conventional treatment,the study group was treated with Shuxuetong on the basis of treatment in the control group.Before and after treatment,24 h urine protein,urea nitrogen(BUN),serum creatinine(Scr),C-reactive protein(CRP),tumor necrosis factor(TNF)-α,malondialdehyde(MDA),superoxide dismutase(SOD)and hemorheology indicators were measured.Results After treatment,the levels of 24 h urinary protein,BUN,Scr,whole blood viscosity(low-cut,high-cut),plasma viscosity,erythrocyte aggregation index,CRP,TNF-α,and MDA in the two groups were lower than those of before treatment(P<0.05),and the level of SOD was higher than that of before treatment(P<0.05).After treatment,the levels of 24 h urine protein,BUN,Scr,whole blood viscosity(low-cut,high-cut),plasma viscosity,erythrocyte aggregation index,CRP,TNF-αand MDA in the study group were lower than those in the control group(P<0.05),and the level of SOD in the study group was higher than that in the control group(P<0.05).Conclusion Alprostadil combined with Shuxuetong is effective in the treatment of type 2 diabetic nephropathy,which can significantly improve the renal function,reduce the level of serum inflammatory factors,improve the oxidative stress state and hemorheology in patients,and is worthy of clinical application.