比索洛尔治疗冠心病的疗效及对患者心功能、炎症因子水平的影响

目的探讨比索洛尔治疗冠心病(CHD)的疗效及对患者心功能、血液流变学、血清炎症因子水平的影响。方法选取2016年10月至2018年12月于该院就诊的CHD患者152例为研究对象,采用随机数表法分为两组,对照组给予CHD常规药物治疗,观察组在对照组基础上加用比索洛尔治疗。比较两组治疗3个月后的疗效、心功能指标左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)与收缩末期内径(LVESD)、6 min步行试验(6MWT)]、血液流变学指标全血黏度高切(HWBV)、黏度低切(LWBV)及血浆黏度(PV)]、血清炎症因子肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6、超敏C反应蛋白(hs-CRP)]、降钙素原(PCT)及氨基末端脑钠肽前体(NT-proBNP)水平。结果观察组总有效率高于对照组(P<0.05)。治疗后两组LVEF与6MWT水平均较治疗前升高(P<0.05),LVEDD、LVESD、LWBV、HWBV、PV、TNF-α、IL-6、hs-CRP、PCT及NT-proBNP水平均较治疗前下降(P<0.05);且治疗后观察组LVEF、6MWT水平均高于对照组,LVEDD、LVESD、LWBV、HWBV、PV、TNF-α、IL-6、hs-CRP、PCT及NT-proBNP水平均低于对照组(P<0.05)。结论比索洛尔治疗CHD疗效确切,可改善患者的心功能与血液流变学,降低机体炎性反应水平。

Treatment effects of bisoprolol on patients with coronary heart disease and its influence on cardiac function and inflammatory factors

Objective To explore the efficacy of bisoprolol in treatment of patients with coronary heart disease(CHD)and its influence on cardiac function,hemorheology and levels of serum inflammatory factors.Methods A total of 152 CHD patients who treated in the hospital from October 2016 to December 2018 were enrolled.They were averagely divided into two groups by random number table method,the control group was given conventional CHD treatment,and the observation group was treated with bisoprolol on the basis of the control group.The clinical effects,cardiac function indexesleft ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD)and end-systolic diameter(LVESD),6 min walking test(6MWT)],hemorheology indexeshigh-cut whole blood viscosity(HWBV),low-cut whole blood viscosity(LWBV)and plasma viscosity(PV)],serum inflammatory factorstumor necrosis factor(TNF)-α,interleukin(IL)-6,high sensitive C-reactive protein(hs-CRP)],procalcitonin(PCT)and N-terminal pro-brain natriuretic peptide(NT-proBNP)levels were compared between the two groups after 3 months of treatment.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the levels of LVEF and 6MWT were higher than before treatment(P<0.05),while the levels of LVEDD,LVESD,LWBV,HWBV,PV,TNF-α,IL-6,hs-CRP,PCT and NT-proBNP were lower than before treatment(P<0.05);after treatment,the levels of LVEF and 6MWT in the observation group were higher than those in the control group,while the levels of LVEDD,LVESD,LWBV,HWBV,PV,TNF-α,IL-6,hs-CRP,PCT and NT-proBNP in the observation group were lower than those in the control group(P<0.05).Conclusion Bisoprolol is effective in the treatment of CHD.It can improve the cardiac function and hemorheology,and reduce the level of inflammatory response.