| 冠状动脉旁路移植术静脉移植物内膜增生的治疗策略 |
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| 引用本文： | 邱雪峰,董念国. 冠状动脉旁路移植术静脉移植物内膜增生的治疗策略[J]. 心血管病学进展, 2009, 30(6) |
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| 作者姓名： | 邱雪峰 董念国 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院心血管外科,湖北,武汉,430022 |
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| 摘 要： | 尽管冠状动脉旁路移植术中动脉桥血管被广泛使用且远期通畅率高,但大隐静脉移植物仍是冠状动脉旁路移植术使用最多的桥血管,而大隐静脉移植物术后10年通畅率大约60%。静脉移植物再狭窄的机制包括血栓形成、心内膜增生和粥样硬化等。防治静脉移植物再狭窄的方案包括药物治疗、基因治疗和血管外支架。现就上述治疗方案作一综述。
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| 关 键 词： | 静脉移植物 内膜增生 外支架 |
Therapeutic Strategies to Reduce Vein Graft Neointima Formation in Coronary Artery Bypass Grafting |
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| QIU Xue-feng,DONG Nian-guo. Therapeutic Strategies to Reduce Vein Graft Neointima Formation in Coronary Artery Bypass Grafting[J]. Advances in Cardiovascular Diseases, 2009, 30(6) |
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| Authors: | QIU Xue-feng DONG Nian-guo |
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| Affiliation: | QIU Xue-feng; DONG Nian-guo(Department of Cardiovascular Surgery; Union Hospital; Tongji Medical College; Huazhong University of Science and Technology; Wuhan 430022; China); |
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| Abstract: | Although arterial conduits are widely used and have good long-term results in coronary artery bypass grafting, vein grafts remain using most in coronary surgery. Newer studies show a saphenous vein graft patency of about 60% at 10 years postoperatively. The pathology of vein graft disease consists of thrombosis, neointimal hyperplasia, and atherosclerosis. Therapeutic strategies to prevent vein graft disease include pharmacotherapy, gene therapy and external stenting. In this review we have summarized a variety of therapeutic strategies for vein graft disease. |
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| Keywords: | vein graft neointimal hyperplasia external stent |
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