| Smad蛋白调控角膜新生血管发生发展的研究进展 |
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| 引用本文： | 曾澳,闫语,王淑荣,张妍,何宇茜.Smad蛋白调控角膜新生血管发生发展的研究进展[J].眼科新进展,2022,0(1):075-78. |
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| 作者姓名： | 曾澳 闫语 王淑荣 张妍 何宇茜 |
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| 作者单位： | 130041 吉林省长春市，吉林大学第二医院眼科中心(曾澳，闫语，王淑荣，张妍，何宇茜)；130021 吉林省长春市，吉林大学白求恩医学部（曾澳，闫语） |
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| 基金项目： | 吉林省科技厅国际科技合作项目(编号20200801016GH);吉林省科技厅自然科学基金(编号20180101146JC)。 |
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| 摘 要： | 角膜新生血管（CNV）是一种严重的致盲性病理改变，与多种眼表疾病的发生发展密切相关。在CNV发生发展过程中，多种蛋白参与调控。研究表明，Smad蛋白可通过多种信号通路影响CNV的发生发展。本文就近年来Smad蛋白调控CNV发生发展的研究进展作一综述。
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| 关 键 词： | Smad蛋白 角膜新生血管 转化生长因子-β 骨形态发生蛋白 茎细胞 尖细胞 |
Research progress of Smad protein in regulating the occurrence and development of corneal neovascularization |
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| ZENG Ao,YAN Yu,WANG Shurong,ZHANG Yan,HE Yuxi.Research progress of Smad protein in regulating the occurrence and development of corneal neovascularization[J].Recent Advances in Ophthalmology,2022,0(1):075-78. |
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| Authors: | ZENG Ao YAN Yu WANG Shurong ZHANG Yan HE Yuxi |
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| Institution: | 1.Department of Ophthalmology,the Second Hospital of Jilin University,Changchun 130041,Jilin Province,China2.Bethune College of Medicine,Jilin University,Changchun 130021,Jilin Province,China |
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| Abstract: | Corneal neovascularization(CNV)is a serious blinding lesion closely associated with the occurrence and development of various ocular surface diseases.In the process of CNV,many proteins participate in the regulation.Studies have shown that Smad protein can influence the occurrence and development of CNV through multiple signaling pathways.This paper summarizes the research progress of Smad protein in regulating the occurrence and development of CNV. |
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| Keywords: | Smad protein corneal neovascularization transforming growth factorβ bone morphogenetic protein stem cells tip cells |
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