探讨大量蛋白尿紫癜性肾炎患儿高尿酸血症与肾脏临床指标及牛津病理分型的关联性

目的 探究大量蛋白尿紫癜性肾炎患儿高尿酸血症与肾脏临床指标及牛津病理分型的关联性.方法 选取2017年1月至2019年12月海南医学院第二附属医院儿科收治的52例大量蛋白尿紫癜性肾炎患儿作为研究对象.根据患儿的尿酸水平将其分为尿酸增高组(n=31)和尿酸正常组(n=21).对比分析两组的肾脏临床指标和牛津病理分型的差异...

The relationship between hyperuricemia and renal clinical indicators and Oxford pathological classification in children with massive proteinuria and henoch-schonlein purpura nephritis

Objective To explore the relationship between hyperuricemia and renal clinical indicators and Oxford pathological classification in children with massive proteinuria and henoch-schonlein purpura nephritis(HSPN).Methods 52 children with massive proteinuria and HSPN admitted to the Department of Pediatrics of the Second Affiliated Hospital of Hainan Medical College from January 2017 to December 2019 were selected as the research objects.According to their uric acid level,children were divided into high uric acid group(n=31)and normal uric acid group(n=21).The differences between the two groups of renal clinical indicators and Oxford pathological types were compared and analyzed,and the correlation between hyperuricemia and renal clinical indicators and Oxford pathological types was explored.Results The proportion of children with hypertension in the high uric acid group was significantly higher than that in the normal uric acid group.The clinical indicators in the high uric acid group were higher than those in the normal uric acid group.The levels of glomerular and renal tubular function-related urinary protein in the high uric acid group were higher than those in the normal uric acid group,with statistical significance(P<0.05).There was no significant difference in the hyperplasia of mesangial cells(M)and endothelial cells(E)between the two groups(P>0.05).The proportion of S1 in the high uric acid group was significantly higher than that in the normal uric acid group,and the difference was statistically significant(P<0.05).In the case of tubule atrophy or interstitial fibrosis(T),the ratio of T1 and T2 in the high uric acid group was significantly higher than that in the normal uric acid group,and the difference was statistically significant(P<0.05).Conclusions The clinical indicators and pathological manifestations of children with HSPN combined with massive proteinuria and hyperuricemia are more serious than those of children with normal uric acid,suggesting that hyperuricemia is an important factor affecting renal function in children with massive proteinuria and henoch-dchonlein purpura nephritis.