79例妊娠合并系统性红斑狼疮临床资料分析

目的　探讨影响妊娠合并系统性红斑狼疮 (SL E)妊娠结局的相关因素 ,提出 SL E患者最佳的受孕时机和孕期的监护 ,预防妊娠 SL E的恶化及 SL E对妊娠的不良影响 ,以提高围产质量。　方法　回顾分析 79例妊娠合并 SL E的临床资料。　结果　妊娠合并 SL E其新生儿体重明显低于正常妊娠组 ,二次以上妊娠组新生儿妊娠结局较初次妊娠组差。在 SL E活动期受孕者其妊娠结局亦较在 SL E缓解期受孕组差 ,SL E肾炎型孕妇妊娠结局较非肾炎型组差。　结论　 SL E患者应首先控制疾病的活动 ,在产科医师和内科医师的指导下受孕 ,并应避免多次妊娠对下次妊娠结局带来的不利影响。泼尼松是目前安全可靠的妊娠期预防 SL E恶化 ,控制 SL E活动的药物之一。 SL E孕妇应加强孕产期的监护 ,以争取良好的妊娠结局

A Clinical Analysis of 79 Cases of Pregnancy Complicated with SLE

Objective To investigate the correlative factors that affect the outcome of pregnancy complicated with SLE and try to provide the best chance for conception, pregnant monitoring, prevent the deterioration of SLE and improve the perinatal quality.Methods Retrospect analysis of 79 cases of pregnancy complicated with SLE. Results The birth weight in the group of pregnancy with SLE was lower than that in the normal group. The outcomes (weight and gestational weeks) of pregnancy in multipara, and nephrolupus groups were poorer than those in primigravida, and in non nephrolupus. The outcomes of pregnancy with SLE in active stage at the beginning of conception were poorer than those in stationary or remission stage. Conclusions The results show that first of all, the activity of SLE should be controlled and patients should get conception under the guide of the obstetricians and physicians, multi pregnancy also should be avoided. Prednisone is one of the safe drugs for pregnant women to control the activation of SLE and to prevent from deterioration. Intensive monitors should be offered to pregnant women complicated with SLE to acquire a better pregnancy outcome.