| HBV感染者基因型、HBVDNA、HBV cccDNA、ALT血清水平变化与抗病毒治疗相关性分析 |
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| 引用本文： | 杜同信,王自正,立彦,傅雷,洪定玲,颜宁.HBV感染者基因型、HBVDNA、HBV cccDNA、ALT血清水平变化与抗病毒治疗相关性分析[J].标记免疫分析与临床,2009,16(5). |
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| 作者姓名： | 杜同信 王自正 立彦 傅雷 洪定玲 颜宁 |
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| 作者单位： | 1. 南京医科大学附属南京第一医院中心实验室,江苏,南京,210006
2. 南京医科大学附属南京第一医院感染科,江苏,南京,210006 |
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| 摘 要： | 为检测HBV感染者基因型及血清HBV DNA、HBV cccDNA、ALT、HBeAg水平,探讨它们之间相互关系及治疗后与这些指标的相关性,采用PCR荧光定量、基因测序、化学发光、生化分析等方法,分别对收集的202例HBV感染的患者Lamivudine抗病毒治疗前后的血清HBV DNA、HBV cccDNA、 ALT、 HBeAg定量检测及HBV DNA基因分型.结果显示,HBV B型和C型患者的血清 HBV DNA和cccDNA的水平没有显著性差异,HBV cccDNA与HBV DNA的比值也没有显著性差异;HBV B型和C型患者的血清 HBV DNA和cccDNA的水平与ALT有相关性;不管是HBV B型还是C型的患者,HBeAg阳性的患者血清中HBV DNA和cccDNA显著高于HBeAg阴性的患者;但是,C型的患者,HBeAg阳性的患者cccDNA与HBV DNA的比值显著低于HBeAg阴性的患者;治疗后比治疗前除 HBeAg没有显著性差异(P>0.05),HBV DNA、cccDNA、ALT均有显著性差异(P<0.01).感染HBV B型和C型的患者血清 HBV DNA和cccDNA的水平无显著性差异;而C型的患者,HBeAg阳性的患者cccDNA与HBV DNA的比值显著低于HBeAg阴性的患者;HBV DNA基因型、HBV cccDNA、ALT与抗病毒治疗密切相关.
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| 关 键 词： | 乙型肝炎病毒 基因型 拉米呋定 |
The Relationship Between the Genotype,Serum Levels of HBV DNA,HBV cccDNA,ALT and Anti-virus Therapy in Patients with HBV Infection |
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| DU Tong-xin,WANG Zi-zheng,LI Yan,FU Lei,HONG Ding-ling,YAN Ning.The Relationship Between the Genotype,Serum Levels of HBV DNA,HBV cccDNA,ALT and Anti-virus Therapy in Patients with HBV Infection[J].Labeled Immunoassays and Clinical Medicine,2009,16(5). |
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| Authors: | DU Tong-xin WANG Zi-zheng LI Yan FU Lei HONG Ding-ling YAN Ning |
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| Institution: | DU Tong-xin,WANG Zi-zheng,LI Yan,FU Lei,HONG Ding-ling,YAN Ning(Central Laboratory of Nanjing First Hospital Affiliated to Nanjing Medical University,Nanjing 210006,China) |
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| Abstract: | To detect the HBV genotypes and the serum levels of HBV DNA,HBV cccDNA,ALT and HBeAg in patients with HBV infection before and after anti-virus therapy,and to explore the relationship between them,the HBV genotypes and the serum levels of HBV DNA,HBV cccDNA,ALT and HBeAg in 202 patients with HBV infection before and after one circle anti-virus therapy with Lamivudine were detected by using real-time quantitative PCR,gene sequencing,chemiluminescent and biochemical methods.The results showed that there was n... |
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| Keywords: | HBV cccDNA HBV DNA |
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