Treatment with atorvastatin improves small artery compliance in patients with severe hypercholesterolemia |
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Institution: | 1. Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan;2. Department of Gynecology and Obstetrics, Tohoku University Graduate School of Medicine, Sendai, Japan;3. Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan |
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Abstract: | Background:We studied the effect of atorvastatin on arterial compliance in patients with severe hypercholesterolemia.Methods:Seventeen patients with low-density lipoprotein cholesterol levels above 170 mg/dL, were included in the study, none of whomever received hypolipidemic medication or had other risk factors. Patients were followed for five visits, every 4 weeks.Results:After 20 weeks of treatment, lipid profile improved significantly. Large artery elasticity index did not change significantly, but small artery elasticity index increased by 21% (4.6 ± 0.5 to 5.6 ± 0.9, P < .01). Although none of our patients suffered from hypertension, both systolic and diastolic blood pressure (BP) decreased significantly (6 mm Hg and 3 mm Hg, respectively).Conclusions:We conclude that atorvastatin improves the elasticity of small arteries and reduces systolic and diastolic BP in patients with severe hypercholesterolemia. |
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