| N-乙酰半胱氨酸对吸入性损伤肺表面活性物质结合蛋白A的影响 |
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| 引用本文： | 傅祖红,杨宗城,黎鳌. N-乙酰半胱氨酸对吸入性损伤肺表面活性物质结合蛋白A的影响[J]. 中华烧伤杂志, 2000, 16(3): 173-176 |
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| 作者姓名： | 傅祖红 杨宗城 黎鳌 |
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| 作者单位： | [1]广州军区武汉总医院呼吸科，武汉430070 [2]第三军医大学西南医院烧伤研究所 |
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| 摘 要： | 目的 探讨N-乙酰半胱氨酸(NAC)对烟雾吸入性损伤肺表面活性物质结合蛋白A(SPA)表达及功能活性的影响。方法采用烟雾吸人性损伤的大鼠模型，观察NAC治疗后SPA mRNA表达情况，并检测静态肺顺应性、肺泡灌洗液表面张力及Ⅱ型细胞板层体形态。结果 经NAC治疗后SPA mRNA表达增强，静态肺顺应性增加，肺泡灌洗液表面张力特征恢复正常，Ⅱ型细胞板层体恢复至正常形态。结论 NAC治疗可促进烟雾吸入伤后SPA mRNA表达，并对SPA相关功能活性具有改善作用。
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| 关 键 词： | N-乙酰半胱氨酸 肺表面活性物质结合蛋白A 大鼠 烟雾吸入性损伤 |
The effects of NAC on the expression and activity of SPA in rats inflicted by smoke inhalation injury |
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| FU Zuhong,YANG Zongcheng,LI Ao. The effects of NAC on the expression and activity of SPA in rats inflicted by smoke inhalation injury[J]. Chinese journal of burns, 2000, 16(3): 173-176 |
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| Authors: | FU Zuhong YANG Zongcheng LI Ao |
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| Affiliation: | Department of Respiratory Disease, Wu Han General Hospital of Guang Zhou Military Region, Wu Han 430070, P.R. China. |
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| Abstract: | OBJECTIVE: To investigate the effects of NAC (N-acetyl-L-cysteine) on the expression and activity of SPA (surfactant-associated protein A) in rats inflicted by smoke inhalation injury. METHODS: Wistar rats inflicted with smoke inhalation injury were employed as the model. The expression of SPA mRNA, the static pulmonary compliance, the surface tension of the alveolar lavage and the morphology of lamellae bodies (LB) of type II alveolar cells were examined. RESULTS: After the application of NAC, there exhibited an increase in SPA mRNA expression and static pulmonary compliance, and the restoration of the BAL surface tension to normal. CONCLUSION: The application of NAC could promote the expression of SPA mRNA after smoke inhalation injury and improve the SPA-related function. |
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| Keywords: | Smoke inhalation injury Pulmonary injury Surfactant N-acetyl-L-cysteine Surfactant-associated protein A Lamellae body |
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