| 布洛芬混悬液中布洛芬的质量测定 |
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| 引用本文： | 仇毅,黄文娴,吴卉. 布洛芬混悬液中布洛芬的质量测定[J]. 抗感染药学, 2010, 7(4): 260-261. DOI: 10.3969/j.issn.1672-7878.2010.04-011 |
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| 作者姓名： | 仇毅 黄文娴 吴卉 |
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| 作者单位： | 苏州大学附属儿童医院,江苏苏州215003 |
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| 摘 要： | 目的:确立布洛芬混悬液中布洛芬质量的高效液相色谱法的测定方法。方法:采用XDB-C184.6mm×150mm为分析柱,乙腈:醋酸-醋酸钠缓冲液(60:40)为流动相,流速1.0mL/min,检测波长263nm,柱温4℃。结果:布洛芬在0～0.1mg/mL范围内,质量浓度(p与峰面积响应值(A)线性关系良好。回归方程:A=1500.7p-0.1882(r=0.9996),平均回收率为100.62%,RSD=0.97%。结论:该法操作简便、准确,可用于布洛芬混悬液中布洛芬质量控制。
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| 关 键 词： | 布洛芬 混悬液 高效液相色谱法 含质量测定 |
Quality Determination of Ibuprofen in Suspension by HPLC |
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| QIU Yi,HUANG Wen-xian,WU Hui. Quality Determination of Ibuprofen in Suspension by HPLC[J]. Anti-infection Pharmacy, 2010, 7(4): 260-261. DOI: 10.3969/j.issn.1672-7878.2010.04-011 |
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| Authors: | QIU Yi HUANG Wen-xian WU Hui |
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| Affiliation: | Children＇s Hospital Affiliated to Soochow University,Suzhou Jiangsu 215003,China |
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| Abstract: | Objective：To establish a HPLC method for determination of Ibuprofen in suspension.Methods：HPLC analysis was carried out by employing Symetry C18 column and a mixture of acetonitrile and acetic acid buffer（60：40） as mobilephase.The detection wavelength was at 263 nm and flow rate was 1.0 mL/min.Results：The linear regression equation was A=1 500.7 P-.188 2（r=0.999 6）.linear range was 0~0.1 mg/mL,and the average recovery was 100.62%（RSD=0.97%）.Conclusion：This method is accurate and convenient.Itcan be used to determine Ibuprofen in suspension. |
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| Keywords: | ibuprofen suspension HPLC quality determination |
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