| 血管生成抑制因子的研究进展 |
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| 引用本文： | Wu JX,Xu BL,Huang WL. 血管生成抑制因子的研究进展[J]. 癌症, 2005, 24(3): 376-384 |
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| 作者姓名： | Wu JX Xu BL Huang WL |
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| 作者单位： | 中山大学肿瘤防治中心实验研究部,广东,广州,510060;中山大学肿瘤防治中心实验研究部,广东,广州,510060;中山大学肿瘤防治中心实验研究部,广东,广州,510060 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | 血管生成与肿瘤的生长、侵袭和转移密切相关,目前,以抑制血管生成为靶点治疗肿瘤有望成为抗肿瘤新疗法之一。近年来,研究发现了多种内源性血管生成抑制因子,其中一些已进入了临床试验阶段。本文对内源性血管生成抑制因子的结构、功能、作用机制及其在肿瘤治疗中的应用进行综述。
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| 关 键 词： | 肿瘤 血管生成抑制因子 血管生成抑制素 内皮细胞抑制素 |
| 文章编号： | 1000-467X(2005)03-0376-09 |
| 修稿时间： | 2004-07-27 |
Research advancement of endogenous angiogenesis inhibitors |
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| Wu Jiang-Xue,Xu Ben-Ling,Huang Wen-Lin. Research advancement of endogenous angiogenesis inhibitors[J]. Chinese journal of cancer, 2005, 24(3): 376-384 |
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| Authors: | Wu Jiang-Xue Xu Ben-Ling Huang Wen-Lin |
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| Affiliation: | Research Department, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P.R.China. |
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| Abstract: | Angiogenesis is required for invasive tumor growth and metastasis. Inhibition of angiogenesis is considered to be a promising approach of antitumor therapy. Recently, many endogenous angiogenesis inhibitors have been discovered, some of them are currently in various stages of clinical trials. This review focused on the structure, function, and mechanism of endogenous angiogenesis inhibitors, and their potential in treating tumor. |
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| Keywords: | Neoplasms Angiogenesis inhibitor Angiostatin Endostatin |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
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