Roles of FOXP3 in experimental atherosclerosis of ApoE-knockout mice |
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| Authors: | WANG Zhi-xiao MAO Xiao-bo LIN Jin WANG Cong-quan ZHAN Zhong-qun LI Da-zhu |
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| Affiliation: | WANG Zhi-xiao1,2,MAO Xiao-bo1,LIN Jin1,WANG Cong-quan2,ZHAN Zhong-qun2,LI Da-zhu1 1.Department of Cardiology,Institute of Cardiovascular Diseases,Union Hospital,Tongji Medical College,Huazhong University of Science & Technology,Wuhan 430022,China.2.Taihe Hospital,Hubei Medical University,Shiyan Hubei 442000,China |
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| Abstract: | Background Subtypes of T cells,called regulatory T cells(Treg cell),play a critical role in limiting autoimmune processes and inflammatory responses,The aim of this study was to explore functional roles of FOXP3 in the manifestation of atherosclerosis in Apolipoprotein E deficient(ApoE)-/-mice.Methods Lentivirus-mediated(siRNA) was used to knock down FOXP3 and FOXP3high+CD4+ CD25+ T cells adoptive transfer assays in high fat diet ApoE-/-mice were done.The resulting atherosclerotic lesions were assessed by d... |
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| Keywords: | FOXP3 ApoE-/-mice siRNA lentivirus vector FOXP3 CD4 CD25 Treg cell |
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