流行性出血热体液因子的变化与其发病机理的关系

目的探讨流行性出血热（ＥＨＦ）患者体液因子的变化在其发病机制中的作用。方法应用放射免疫法对８０例ＥＨＦ患者和３１例健康人血浆内源性类洋地黄物质（ＥＤＬＳ）、肾素活性（ＲＡ）和血管紧张素Ⅱ（ＡＴⅡ）进行了检测。结果发现ＥＨＦ患者体液因子与正常对照组比较均有显著性差异（Ｐ＜０．０１），ＥＤＬＳ以低血压休克期、少尿期升高最明显，ＲＡ和ＡＴⅡ在各期均明显升高。测定中还发现它们的含量升高与病情变化程度有一定关系，ＥＤＬＳ与ＲＡ、ＡＴⅡ均呈明显正相关。结论这些体液因子均参与了ＥＨＦ的发病过程，可能是引起ＥＨＦ急性肾功能不全及内环境紊乱的重要介质。

The Relationship between Humoral Factors and Pathogenesis in Epidemic Hemor-rhagic Fever

Objective To investigate the effects ofhumoral factors'changes on the pathogenesis of epi-demic hemorrhagic fcver EHF).Method Endoge-nous digitalis-like stibstance(EDLS).renin activity(RA)aiid aiigiotei1sin Ⅱ(AT Ⅱ)inplasma weremeasured by radioimmunoassay in 80 patients withEHFand in 131 normal controls.Results Tbere wassignificant difference between the levels of humoralfactors in the patients of EHF and in the controls(P<0.01)EDLS in hypotensive and oliguric phasesobviously higher than in the controls, RA、AT Ⅱ allwere higher in every phase, EDLS was positively cor-related to RA and AT Ⅱ(r=0. 9456P<0. 001.r=0.8360 P< 0. 005).Conclusion It is suggested thatthe humoral factors contribute to the pathogenesis of EHF and may be important media that causes acuterenal insufficiency and disordered homeostasis.