血清β_2微球蛋白与肝炎临床病理的关系

目的为探讨血清β＿２－微球蛋白（β＿２－Ｍ）与肝炎组织学变化的关系，对肝炎患者血清β＿２－Ｍ含量与肝炎组织学变化进行对比分析。方法甲ＲＩＡ法测定各型肝炎１６７例血清β＿２－Ｍ含量，其中１１０例同时做肝活检，按照Ｋｎｏｄｅｌｌ肝组织炎症活动指数标准记分。结果与正常人比较，各型肝炎患者血清β＿２－Ｍ均明显升高，以ＡＨ、ＣＡＨ及ＰＨＬＣ更为显著（Ｐ＜０．０５～０．０１）。血清β＿２－Ｍ水平与肝细胞坏死及门管区炎症程度密切相关，而与肝纤维化程度无相关性。结论血清β＿２－Ｍ是反映肝实质炎症性质有价值的血清学指标。

The Relationship between the Levels of Serum β_2-Microglobulin and Clinicopatho-logy of Hepatitis

objective In order to study the rela-tionship between the levels of sertim β_2-microglobulin(β_2-M)and clinicopathology of hepatitis,we com-pared the levels of serum β_2-M with clinicopathologyof hepatitis,Methods The β_2-M of sertim in 167 pa-tients with acute hepatitis,chronic hepatitis andpost-hepatitic liver cirrhosis was determined by RIAkit.Among them liver biopsy was performed in 1 10cases and scored with Knodell's hepatitis activity in-dex(HAI).Results The serum β_2-M levels of pa-tients with acute hepatitis,chronic hepatitis and post-hepatitic liver cirrhosis were all significantly-higher than that of normal controls (P<0.05～0.01).The levels of serum β_2-M were positively corre-lated to the range of necrosis of hepatocyte and thedegrec of inflammation of portal area(r=0. 668;P<0. 01),but not related to the degree of hepatic fibro-sis(r=0;302;P>0.05).Conclusion The determi-nation of serum β_2-M is a useful index for diagnosis of liver parenchymatitis.