| 广东籍2型糖尿病患者1型葡萄糖转运蛋白基因多态性的研究 |
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| 引用本文： | 刘泽林,王玉磷,李路,吴炎,徐丹,王沙燕,石之麟. 广东籍2型糖尿病患者1型葡萄糖转运蛋白基因多态性的研究[J]. 实用口腔医学杂志, 2007, 36(9): 776-777 |
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| 作者姓名： | 刘泽林 王玉磷 李路 吴炎 徐丹 王沙燕 石之麟 |
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| 作者单位： | [1]暨南大学第二附属医院内分泌科,518020 [2]暨南大学第二附属医院临床医学研究中心,518020 |
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| 摘 要： | 目的探讨1型葡萄糖转运蛋白(GLUT1)基因多态性与广东籍2型糖尿病遗传易感性的关系。方法应用聚合酶链反应(PCR)技术对73例广东籍2型糖尿病患者和102名健康人(NT)GLUT1基因多态性进行检测。结果GLUT1基因多态性XbaⅠ(+/+)型、XbaⅠ(+/-)型、XbaⅠ(-/-)型在正常人群和广东籍2型DM患者中的分布频率有一定差异,但无统计学意义(P>0.05)。结论GLUT1基因多态性可能与广东籍2型DM患者的遗传易感性无关。
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| 关 键 词： | 单糖转运蛋白质类 基因 多态性 糖尿病,2型 广东 |
| 修稿时间： | 2007-06-29 |
A study on polymorphism of glucose transporter 1 gene in type 2 diabetes mellitus of Guangdong native place |
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| LIU Ze-lin,WANG Yu-lin,LI Lu,WU Yan,XU Dan,WANG Sha-yan,SHI Zhi-lin. A study on polymorphism of glucose transporter 1 gene in type 2 diabetes mellitus of Guangdong native place[J]. Journal of Practical Stomatology, 2007, 36(9): 776-777 |
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| Authors: | LIU Ze-lin WANG Yu-lin LI Lu WU Yan XU Dan WANG Sha-yan SHI Zhi-lin |
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| Affiliation: | The Second Affiliated Hospital of Jinan University, Shenzhen 518020, China |
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| Abstract: | Objective To explore the relationship between the polymorphism of glucose transporter 1 gene and genetic sensitivity in type 2 diabetes mellitus of Guangdong native place.Methods Glucose transporter 1 gene polymorphism in 73 patients with type 2 diabetes mellitus of guangdong native place,102 healthy subjects were detected by PCR.Results The frequencies of XbaⅠ(+/+)、XbaⅠ(+/-)、XbaⅠ(-/-) gene type in type 2 diabetes mellitus of Guangdong native place and healthy subjects showed no significant differences(P>0.05).Conclusion There might be no relationship between the polymorphism of glucose transporter 1 gene and genetic sensitivity in type 2 diabetes mellitus of Guangdong native place. |
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| Keywords: | Monosaccharide transport proteins Genes Polymorphism Diabetes mellitus, type 2 Guangdong |
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