Optimization of Novel Mucoadhesive In Situ Film Forming Periodontal Drug Delivery System for Chemotherapeutic Agents

Introduction

The objective of the present investigation was to develop and evaluate mucoadhesive in situ film forming periodontal drug delivery system (MIFPDDS) for local delivery of chemotherapeutic agents. Ethyl cellulose, a film forming release retardant, was used in combination with Eudragit RL100, a mucoadhesive polymer, and polyvinylpyrrolidone K-30 to develop MIFPDDS.

Materials and methods

A simplex lattice design was employed to achieve an optimum solvent blend (N-methyl-2-pyrrolidone, polyethylene glycol-200, and propylene glycol) which has rapid film formation capacity and low viscosity. The prepared MIFPDDS was evaluated for various parameters such as in vitro film forming capacity, viscosity, in vitro diffusion study, ex vivo mucoadhesion study, stability study, and compatibility. A 32 full-factorial design was used to investigate the influence of formulation variables.

Results and discussion

Drug release data from all formulations were fitted to different kinetic models, and the Korsmeyer–Peppas model was found the best fit model. Increasing the concentration of each polymeric component increases viscosity, and time for 50, 70, and 90 % drug release was observed and graphically represented by the surface response and contour plots. The formulation of batches MIF1—PCM4, MIF6, and MIF7 failed to give the desired results for the first hour drug release and MIF8 and MIF9 failed to show viscosity below 70 cPs.

Conclusion

The formulation of batch MIF5 containing 3 % (w/v) of ethyl cellulose and 8 % (w/v) of Eudragit RL100 was considered as optimum formulation.