Studies on the Induction of Antibody Synthesis against Sulfanilic Acid in Rabbits. |
| |
| Authors: | B. RUBIN |
| |
| Affiliation: | Immunochemical Laboratory, Bloodbank and Blood Grouping Department, Satens Seruminstitut, Copenhagen, Denmark. |
| |
| Abstract: | The following three results emerged from the present experiments concerning the induction of antibody synthesis against sulfanilic acid: 1) the anti-Sulf antibody response in rabbits seems to be much more carrier-dependent when Sulf is coupled to heterologous serum protein compared to homologous (autologous) serum protein; 2) anti-NAD antibodies (antibodies directed against the new antigenic determinants introduced into the carrier through the coupling with hapten) were able to induce a secondary response to Sulf11RSA in rabbits primarily stimulated with Sulf10BGG; and 3) anti-NAD antibodies were able to induce an immune response to Sulf11RSA in rabbits made unresponsive to Sulf11RSA by i.v. injections of soluble Sulf11RSA. |
| |
| Keywords: | |
|
|
