恶性肿瘤患者血清sIL-2R与免疫功能相关性研究

目的：探讨sIL-2R对各种免疫功能的影响。方法：对30例正常人、16例运动员、50例肺癌、50例恶性淋巴瘤4组人群血清sIL-2R与淋巴细胞对PHA、IL－2反应，NK活性、LAK活性、T细胞亚群、皮肤迟发超敏反应等免疫功能的相关性进行了研究。结果：在正常人群，sIL-2R对上述免疫功能无明显相关，只有在较高的sIL-2R水平条件下（如恶性肿瘤），它与多数功能呈负相关。而且，对不同的免疫功能指标，其相关性有所不同，如对IL－2的细胞反应、NK活性、LAK活性、CD3等有一定的相关性，对PHA淋巴细胞反应，CD4／CD8则相关性不明显，即使是与其相关的免疫功能，其重复性也较差。结论：sIL-2R是一种重要的免疫封闭因子，但在免疫网络中各种细胞因子的相互作用下，其封闭作用（即负相关）表现得时强时弱。

CORRELATION BETWEEN IMMUNOFUNCTION AND sIL-2R IN THE NORMAL POPULATION AND MALIGNANCIES

Objective:Effect of serum IL 2R on immunofunction were studied.Methods:Serum IL 2R and lymphocytic competence to PHA,IL 2,NK activity,LAK activity,subsets of T lymphocytes and delayed skin supersensitization were tested in four groups,including 30 normal controls,16 athletes,50 patients with lung cancer and 50 malignant lymphomas.The correlation between the tested immunofunction in each group were also studied.Results:In normal population,no correlations were found.Malignancies with high level of sIL 2R were negtively correlated with various immunofunctions,such ascytologic competence to IL 2,NK activity,LAK aitivity and number of CD 3.No significant correlation was found in cytologic competence to PHA and ratio of CD 4 and CD 8.Conclusion:sIL 2R is an important blocking factor for immunofunction,but under the interaction between various cytokines in the immunoregulatory network,its blockege is different with strong or week competence.