新诊断2型糖尿病患者GADA和ZnT8A自身抗体检测意义研究

目的 分析新诊断2型糖尿病患者中谷氨酸脱羧酶自身抗体(GADA)和锌转运子8自身抗体(ZnT8A)阳性情况。方法 通过ELISA法检测2014年5月～10月收集的101例新诊断2型糖尿病患者血清样本GADA和ZnT8A水平。结果 GADA阳性率为21.78%,ZnT8A阳性率为17.82%,两种自身抗体共同阳性率为8.91%,且GADA和ZnT8A阳性与否与患者的性别(t=-0.724,-0.550; 0.903,1.359,P值均＞0.05)、年龄(r=-0.185,-0.158; 0.367,0.084,P值均＞0.05)、血糖(r=0.290,0.110; -0.264,-0.047,P值均＞0.05)、胆固醇(r=-0.047,0.004; 0.154,-0.138,P值均＞0.05)、三酰甘油(r=-0.092,-0.054; -0.217,-0.023,P值均＞0.05),以及低密度脂蛋白(r=-0.045,-0.027; 0.202,-0.025,P值均＞0.05)水平不存在明显相关性。结论 为了早期诊断成人迟发型自身免疫性糖尿病患者,应该对新诊断的2型糖尿病患者及时进行自身抗体的筛查。

Role of Detecting GADA and ZnT8A in Newly Diagnosed Type 2 Diabetes Patients

Objective To analysis the positive rates of glutamic acid decarboxylase autoantibody(GADA)and zinc transporter 8 autoantibody(ZnT8A)in newly diagnosed type 2 diabetes patients.Methods GADA and ZnT8A were detected in 101 cases of newly diagnosed type 2 diabetes mellitus patients using ELISA.Results The positive rate of GADA was 21.78%,the positive rate of ZnT8A was 17.82%,and the common positive rate of GADA and ZnT8A was 8.91%.There were no correlations between GADA or ZnT8A autoantibodies and the patient's sex(t=-0.724,-0.550; 0.903,1.359,P＞0.05),age(t=-0.724,-0.550; 0.903,1.359,P＞0.05),blood glucose(r=0.290,0.110; -0.264,-0.047,P＞0.05),cholesterol(r=-0.047,0.004; 0.154,-0.138,P＞0.05),triglyceride(r=-0.092,-0.054; -0.217,-0.023,P＞0.05),and low density lipoprotein(r=-0.045,-0.027; 0.202,-0.025,P＞0.05).Conclusion It should be screened autoantibodies timely for newly diagnosed type 2 diabetic patients in order to diagnosis the Latent autoimmune diabetes in adults early.