SLE患者血清胱抑素C与血脂的相关性分析

目的 探讨系统性红斑狼疮(SLE)患者血清胱抑素C(Cys C)与血脂的相关性及其临床意义。方法 采用全自动生化仪测定136例SLE患者和113例体检健康者的血清胱抑素C(Cys C)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和超敏C反应蛋白(hsCRP)浓度。所得数据用SPSS13.0统计软件进行统计分析。结果 SLE患者组与健康对照组比较,血清hsCRP(13.5±4.85 mg/L vs 2.03±0.88 mg/L),Cys C(2.63±1.95mg/L vs 0.85±0.37 mg/L),LDL-C(3.06±1.21 mmol/L vs 2.33±0.41 mmol/L),TC(5.32±2.63 mmol/L vs 4.02±1.67 mmol/L)和TG(1.92±0.83 mmol/L vs 1.44±0.8 mmol/L),显著高于健康对照组,两组比较差异有统计学意义(t=2.45～12.4,P值均＜0.05); 与健康对照组比较,SLE组患者HDL-C(1.12±0.31 mmol/L vs 1.52±0.85 mmol/L)水平降低(P值＜0.01)。SLE患者组血清Cys C与hsCRP水平和TG,TC,LDL-C水平呈正相关(P值＜0.01),和HDL-C水平呈负相关(P值＜0.01),而健康对照组无明显相关性(P值＞0.05)。结论 SLE患者血清Cys C水平升高与血脂水平存在明显相关性,联合检测SLE患者血清Cys C和血脂指标对SLE患者并发心血管疾病和动脉粥样硬化疾病进行预防、早期诊断和治疗有重要意义。

Correlation Analysis of Serum Cystatin C and Lipids Levels in Patients with Systemic Lupus Erythematosus

Objective To discuss the correlation betweenthe level of serum cystatin C and lipids in patients with system lupus erythematosus.Methods Used automatic biochemical analyzer to detect serum cystatin C(CysC),triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)and hsCRP levels in 136 cases of SLE patients and 113 cases of healthy people.Data obtained using SPSS13.0 software to carry on statistical analysis.Results Outcome of SLE patients group compared with healthycontrols,hsCRP(13.5±4.85 mg/L vs 2.03±0.88 mg/L),CysC(2.63±1.95 mg/L vs 0.85±0.37 mg/L),LDL-C(3.06±1.21 mmol/L vs 2.33±0.41 mmol/L),TC(5.32±2.63 mmol/L vs 4.02±1.67 mmol/L)and TG(1.92±0.83 mmol/L vs 1.44±0.8 mmol/L)were significantly higher the difference between groups was statistically significant(t=2.45～12.4,P＜0.05).Compared with healthycontrols,HDL-C(1.12±0.31 mmol/L vs 1.52±0.85 mmol/L)was decreased(P＜0.01).In SLE patients group,the serum CysC level and hsCRP,TC,TG andLDL-C were positively correlated,and the level of HDL-C was negative to thelevel of CysC.The health control group was no significant correlation.Conclusion Serum lipid levels of SLE patients were positive to the level of CysC.Suggest that joint detection of SLE patients serum CysC and blood lipids index is helpful to the diagnosis of SLE treatment and condition monitoring.