| MicroRNAs作为结直肠癌潜在标记物的研究进展 |
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| 引用本文： | 王钦君1,2,张红春2,申娴娟1,鞠少卿1. MicroRNAs作为结直肠癌潜在标记物的研究进展[J]. 现代检验医学杂志, 2015, 0(4): 107-110. DOI: 10.3969/j.issn.1671-7414.2015.04.031 |
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| 作者姓名： | 王钦君1 2 张红春2 申娴娟1 鞠少卿1 |
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| 作者单位： | 1.南通大学附属医院外科综合实验室,江苏南通 226001; 2.启东市人民医院检验科,江苏启东 226200 |
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| 摘 要： | 微小RNA(miRNAs)是一种非编码的内源性RNA分子,miRNAs 的异常表达与疾病,尤其与恶性肿瘤的发生、发展存在密切的关系。研究证明,miRNAs可以作为结直肠癌(colorectal cancer,CRC)早期诊断、治疗、预后的新的分子生物学标志物,同时,miRNAs可作为体内CRC治疗的靶点。该文旨在对与CRC相关的miRNAs的表达、功能、作用机制、靶基因等及其在临床应用前景等方面作一综述。
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| 关 键 词： | 微小RNA 结直肠癌 生物学标志物 靶点 |
MicroRNAs as a Potential Marker in the Progress of Colorectal Cancer |
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| WANG Qin-jun1,' target="_blank" rel="external">2,ZHANG Hong-chun2,SHEN Xian-juan1,JU Shao-qing1. MicroRNAs as a Potential Marker in the Progress of Colorectal Cancer[J]. Journal of Modern Laboratory Medicine, 2015, 0(4): 107-110. DOI: 10.3969/j.issn.1671-7414.2015.04.031 |
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| Authors: | WANG Qin-jun1,' target=" _blank" rel=" external" >2,ZHANG Hong-chun2,SHEN Xian-juan1,JU Shao-qing1 |
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| Affiliation: | 1.Surgical Comprehensive Laboratory,Affiliated Hospital of Nantong University,Jiangsu Nantong 226001,China; 2.Department of Clinical Laboratory,Qidong People's Hospital,Jiangsu Qidong 226200,China |
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| Abstract: | MicroRNAs(miRNAs)are small,non-coding RNAs that regulate the translation of specific protein coding genes.Recent studies have revealed the role of miRNAs in a variety of basic biological and pathologicalprocesses.Previous studies have suggested miRNAs can be servered as a new tumor biomarker in the early diagnosis,treatment and assessment of prognosis of CRC,which also can be servered as the treatment target in vivo of CRC patients.This paper reviews the expression and targets of miRNAs,its mechanism of the development and prospect in clinical application in CRC. |
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