武汉地区冠心病患者氯吡格雷药物代谢相关基因CYP2C19的多态性分布分析

目的 探讨武汉地区冠心病介入患者氯吡格雷代谢相关基因CYP2C19多态性的分布。方法 选取2014年1月～12月武汉大学人民医院心内科进行介入治疗(PCI)的316例冠心病患者作为研究对象。通过基因芯片法检测氯吡格雷代谢相关的CYP2C19*1,*2,*3基因,并将患者按CYP2C19基因型别分为不同代谢类型:强代谢型(*1/*1),中间代谢型(*1/*2,*1/*3),弱代谢型(*2/*2,*3/*3,*2/*3)。结果 根据CYP2C19基因多态性位点功能代谢分型,携带CYP2C19*1的强代谢型(*1/*1)占43.4%,携带CYP2C19*2或*3的中间代谢型(*1/*2和*1/*3)及弱代谢型(*2/*2,*2/*3和*3/*3)分别占42.4%,14.2%。不同性别在CYP2C19基因分型上差异无统计学意义。结论 武汉地区冠心病介入患者中分布有较多的CYP2C19氯吡格雷代谢功能缺失基因。

Analysis of the Polymorphism Distribution of Clopidogrel Metabolism Related Gene CYP2C19 in Patients with Coronary Artery Disease in Wuhan

Objective To screen for clopidogrel metabolismrelated gene CYP2C19 in patients with coronary artery disease in Wuhan.Methods 316 patients,from Jan to Dec 2014,after cardiology percutaneous coronary interventional therapy(PCI)for the treatment of coronary artery disease were selected as research object.Clopidogrel metabolism related CYP2C19 genotypes(*1,*2,*3)were detected by the gene chip,and for different types of metabolism of patients according to CYP2C19 gene type:strong metabolizetype(*1/*1),intermediate metabolizer types(*1/*2,*1/*3),poor metabolizer types(*2/*2,*3/*3,*2/*3).Results According to the CYP2C19 gene polymorphism of metabolic function type,strong metabolic type carryingCYP2C19*1(*1/*1)accounted was 43.4%,intermediate metabolizers carrying CYP2C19*2 or *3(*1/*2 and *1/*3)and poor metabolizers(*2/*2,*2/*3 and *3/*3)accounted was 42.4% and 14.2%,respectively.Different gender had no statistical significance in CYP2C19 genotype differences.Conclusion Clopidogrel metabolism functional of CYP2C19 gene in patients with interventionalcoronary heart disease in Wuhan area had more deletion gene.