胎膜早破孕妇生殖道感染病原菌的分布及耐药性分析

目的 了解胎膜早破孕妇生殖道病原菌的分布及其耐药情况,为临床合理使用抗生素提供指导。方法 对2011～2013年3 162例胎膜早破孕妇生殖道标本进行一般细菌培养、支原体培养、衣原体检测,使用VITEKⅡ型全自动微生物鉴定仪进行鉴定和药敏试验; 所有数据采用WHONET5.6软件进行回顾分析。结果 感染率为33.30%。其中细菌、真菌、支原体培养及沙眼衣原体抗原检测的阳性率分别为13.19%,4.87%,24.89%和2.72%。大肠埃希菌产超广谱β内酰胺酶(ESBLS)的比率为13.76%,耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)的比率分别为27.27%和66.25%。支原体对米诺霉素、强力霉素最敏感。结论 支原体感染为第一位,其次为细菌,临床应加强感染病原学监测,根据药敏试验结果合理使用抗生素。

Distribution and Drug Resistance of Genital Tract Pathogenic Bacteria in Pregnant Women with Premature Rupture of Membrane

Objective To investigate the distribution and drug resistance of genital tract pathogens in pregnant women with premature rupture of membranes(PROM),and provide guidance for clinical rational use of antibiotics.Methods From 2011 to 2013,3 162 cases of patientswith premature rupture of membranes were cultured for bacteria,Mycoplasmaand Chlamydia.Identification and drug sensitive test of the bacteria were detected by VITEK II system; all of the data were analyzed by WHONET5.6 software.Results The rate of infection was 33.30%,in which thepositive rate of bacteria,Fung,Mycoplasma culture and Chlamydia trachomatis antigen detection were 13.19%,4.87%,24.89% and 2.72% respectively.The ratio of Escherichia coli producing extended spectrum beta lactamases(ESBLS)were 13.76%.The ratio of Methicillin resistant Staphylococcus aureus(MRSA)and Methicillin resistant coagulase negative Staphylococcus(MRCNS)were 27.27%and 66.25% respectively.Mycoplasma was most sensitive to minocycline,doxycycline.Conclusion Mycoplasma infection was the first,followed by bacteria.clinical should strengthen the surveillance of pathogen infection,and rational use of antibiotics according to the results of drug sensitive test.