| 粗根老鹳草化学成分的研究 |
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| 引用本文： | 雷海民,魏露雪,林文翰. 粗根老鹳草化学成分的研究[J]. 药学学报, 2000, 35(1): 67-69 |
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| 作者姓名： | 雷海民 魏露雪 林文翰 |
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| 作者单位： | 1. 北京医科大学天然药物及仿生药物国家重点实验室,北京,100083
2. 北京中医药大学,北京,100029 |
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| 摘 要： | 老鹳草为传统中药，有祛风湿、通经络、止泄痢的功效，其单味制剂老鹳草软膏有消炎解毒、收敛生肌的作用［１］。粗根老鹳草作为老鹳草的药材来源之一，分布较广，使用较多［２］，但其化学成分却不清楚，本文对其化学成分进行系统研究，从中分离到５个化合物，其中２个为新化合物。现报道如下：化合物Ｉ 黄色粉末，ｍｐ１１９～１２０℃。ＦＡＢＭＳ（ｍ／ｅ）：３４７（Ｍ＋１）＋，１８５（Ｍ＋１－１６２）＋，１５３。结合１ＨＮＭＲ和１３ＣＮＭＲ确定该化合物的分子组成为Ｃ１４Ｈ１８Ｏ１０，并由葡萄糖、没食子酰基、甲基组成。…
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| 关 键 词： | 粗根老鹳草；没食子酸甲酯；槲皮素；杨梅素 |
| 收稿时间： | 1999-04-07 |
| 修稿时间： | : |
CHEMICAL CONSTITUENTS OF GERANIUM DAHURICUM DC |
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| Lei Haimin,Wei Luxue,Lin Wenhan. CHEMICAL CONSTITUENTS OF GERANIUM DAHURICUM DC[J]. Acta pharmaceutica Sinica, 2000, 35(1): 67-69 |
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| Authors: | Lei Haimin Wei Luxue Lin Wenhan |
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| Affiliation: | Lei Haimin, and Lin Wenhan(National Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences,Beijing Medical University, Beijing 100083)Wei Luxue(Beijing University of Traditional Chinese Medicine, Beijing 100029) |
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| Abstract: | AIM：To investigate the chemical constituents of Geranium dahuricum DC. METHODS: Components were separated by means of solvent extraction and chromatography on Toyopeal and Sephadex-LH20, The structures were determined by spectral analysis and chemical evidences. RESULTS: Five compounds were obtained and elucidated as methyl 3-O-(β-D-glucopyranosyl) gallate (I), methyl 3-O-［β-D-(6′-O-galloyl)-glucopyranosyl］ gallate (II), quercetin-3-O-β-D-galactopyranoside (III), myricetin-3-O-β-D-galactopyranoside (IV), myricetin-3-O-α-L-rhamnopyranoside (V). CONCLUSION: These compounds were separated from this plant for the first time, where I and II were new natural products. |
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| Keywords: | Geranium dahuricum DC methyl gallate quercetin myricetin |
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