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| 鼻息肉及变应性鼻炎中IL-17表达与嗜酸粒细胞浸润的意义 | |
| 引用本文： | 巴罗,杜进涛,刘亚峰,尚婷婷,杨风林,边片.鼻息肉及变应性鼻炎中IL-17表达与嗜酸粒细胞浸润的意义[J].临床耳鼻咽喉头颈外科杂志,2010,24(2). |
| 作者姓名： | 巴罗 杜进涛 刘亚峰 尚婷婷 杨风林 边片 |
| 作者单位： | 1. 四川大学华西医院耳鼻咽喉头颈外科,成都,610041;西藏自治区人民医院耳鼻咽喉科 2. 四川大学华西医院耳鼻咽喉头颈外科,成都,610041 3. 西藏自治区人民医院耳鼻咽喉科 |
| 摘 要： | 目的:观察鼻息肉与变应性鼻炎中IL-17表达与嗜酸粒细胞(Eos)浸润情况,探讨IL-17与Eos在其发病中作用及相关性。方法:采用免疫组织化学SP法检测鼻息肉21例、变应性鼻炎18例及单纯中隔偏曲12例中IL-17表达情况,苏木精-伊红染色下观察炎性细胞浸润并计数Eos进行比较分析。结果:①发现在变应性鼻炎鼻黏膜下固有层、鼻息肉组织上皮层及间质内Eos、中性粒细胞为主的炎性细胞及部分腺体内有IL-17表达;②检测3组中免疫组织化学IL-17阳性细胞数、IOD(IL-17阳性表达吸收度值)及苏木精-伊红染色Eos计数,发现鼻息肉与变应性鼻炎间差异无统计学意义(P>0.05),但均高于正常对照组,差异有统计学意义(P<0.05)。Eos数与IL-17阳性细胞数在鼻息肉中存在正相关性,相关系数r=0.606,P<0.01,在变应性鼻炎中两者亦有相关性,相关系数R=0.446,P<0.05。结论:①IL-17是一种新型的细胞因子,在鼻息肉组织与变应性鼻炎鼻黏膜组织中有表达,因此在发病过程中可能起调节免疫炎症反应作用,可做为深入研究鼻息肉与变应性鼻炎发病机制的指标;②推断在鼻息肉及变应性鼻炎发病中IL-17亦有趋化E... |
| 关 键 词： | 白细胞介素-17 嗜酸粒细胞 鼻炎 变应性 鼻息肉 免疫组织化学 |
The expression and significance of interleukin-17 and the infiltrating eosinophils in nasal polyps and nasal mucous of allergic rhinitis |
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| BA Luo,DU Jintao,LIU Yafeng,SHANG Tingting,YANG Fengling,BIAN Pian.The expression and significance of interleukin-17 and the infiltrating eosinophils in nasal polyps and nasal mucous of allergic rhinitis[J].Journal of Clinical Otorhinolaryngology,2010,24(2). | |
| Authors: | BA Luo DU Jintao LIU Yafeng SHANG Tingting YANG Fengling BIAN Pian |
| Institution: | 1Department of Otolaryngology Head and Neck Surgery/a>;Western China Hospital of Sichuan University/a>;Chengdou/a>;610041/a>;China/a>;2Department of Otolaryngology/a>;People's Hospital of the Tibet Autonomous Region |
| Abstract: | Objective:To observe the expression of interleukin-17 and the infiltration of eosinophilic cells in nasal polyps and allergic rhinitis,and investigate the roles of IL-17 and eosinophils in the etiology of nasal polyps and allergic rhinitis.Method:A study was conducted on 21 patients of nasal polyps,18 ones of allergic rhinitis and 12 normal individuals.Immunohistochemical stain with the rabbit monoclonal antibodies of IL-17 was carried out.The eosinophilic cells infiltrated in different tissues were stained... |
| Keywords: | interleukin-17 eosinophils rhinitis allergic nasal polyps immunohistochemistry |
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