琥珀酸美托洛尔缓释片治疗急性心肌梗死的疗效观察

目的观察早期应用琥珀酸美托洛尔缓释片治疗急性心肌梗死的临床疗效。方法选择急性心肌梗死125例,随机分为两组,琥珀酸美托洛尔缓释片组63例和酒石酸美托洛尔组62例,前者在常规治疗基础上予琥珀酸美托洛尔缓释片23.75～90mg口服,一次/日,后者在常规治疗基础上给酒石酸美托洛尔片12.5～75mg口服,2次/日,治疗4周,观察其对心率,心律失常,心源性休克,死亡及心绞痛的影响,P<0.05。结果观察组在提高心率变异,降低心源性休克,猝死,缩小梗死面积,缓解疼痛方面均优于对照组。结论急性心肌梗死早期使用美托洛尔缓释片可改善心梗预后。

The Effects of Metoprolol Sustained-released Tablets on Heart Rates of Patients with Acute Myocardial Infarction

Objective To observe the clinical effects of the heart rates of patients with acute myocardial infarction after taking metoprolol succinate sustainedrelease tablets in the early phase.Methods 125 acute myocardial infarction patients were randomly assigned to group A(n=63) and group B(n=62).Group A were treated with metoprolol succinate sustained-release tablets 23.75-90mg/d,once daily,Group B were treated with metoprolol tartrate tablets 23.75-90mg/ d.Besides,both group was remedied on the basis of conventional treatment.And to observe the impact in heart rate、arrhythmia、cardiogenic shock、 death and stenocardia after four-week’s treatment,P<0.05.Result The servation group had advantage in improving cardiac variation,reducing cardiogenic shock,sudden death and infarct size and relieving pain than matched group.Conclusion The early use of metoprolol succinate sustained-release tablets in the AMI will improve myocardial infarction prognosis.