| 高效液相色谱法测定双氯灭痛β－环糊精包合物生物利用度 |
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| 引用本文： | 宋伟明,朱彩凤,高钟镐,李凤龙.高效液相色谱法测定双氯灭痛β－环糊精包合物生物利用度[J].延边医学院学报,1994(4). |
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| 作者姓名： | 宋伟明 朱彩凤 高钟镐 李凤龙 |
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| 作者单位： | 延边医学院药剂学教研室，吉林省神经精神病医院药剂科 |
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| 摘 要： | 用高效液相色谱法测定了单纯双氯灭痛、双氯灭痛β－环糊精包合物（共沉淀法、冷冻干燥法）三种样品在家兔体内的血浓度，在ＩＢＭ计算机上求算药动学参数。相对生物利用度分别为８４７．５１８％（共沉淀法），８７８．５２３％（冷冻干燥法）．双氯灭痛在体内的分布呈一室模型。
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| 关 键 词： | 双氯灭痛 环糊精类 生物学效用 |
Determination of bioavailability of diclofenac sodium β-cyclodextrin inclusion by high performance liquid chromatography |
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| Song Weiming,Zhu Caifeng,Gao Zhonggao, Li Fenglong.Determination of bioavailability of diclofenac sodium β-cyclodextrin inclusion by high performance liquid chromatography[J].Journal of Medical Science Yanbian University,1994(4). |
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| Authors: | Song Weiming Zhu Caifeng Gao Zhonggao Li Fenglong |
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| Abstract: | The plasma concentrations of the intact diclofenac sodium (coprecipitation method),diclofenac sodium β-cyclodextrin inclusion compound(coprecipitation method and freeze-dried method) in rabbits were determined by high performance liquid chromatography, and the pharmacokinetcs parameters were calculated using IBM computer.The relativebioavailabilities were 847. 51 8%(coprecipitation method),878.523%(freeze-dried method),respectively. Distribution of diclofenac sodium in the plasma of rabbit showed open one compartment linear model. |
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| Keywords: | diclofenac sodium cyclodextrins biological availability |
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