他汀类药物对脑梗死患者血清超敏C反应蛋白的影响及预后评价

目的：探讨脑梗死患者血清超敏C-反应蛋白（hs—CRP）水平的变化及神经功能缺损的关系，进而了解他汀类药物对脑梗死患者血清hs—CRP水平及预后的影响。方法：采用随机、双盲、安慰剂对照的方法进行研究，将40例脑梗死患者分为对照组和他汀组（辛伐他汀40mg／d，连续2周），治疗前后检测血清hs—CRP水平，并进行神经功能缺损评分比较。结果：他汀组血清hs—CRP水平降低明显，与对照组比较有显著性差异（P〈0．05），神经功能缺损程度评分比较他汀组下降较明显，与对照组比较有显著性差异（P〈0．05）。结论：脑梗死患者血清hs—CRP与预后相关，应用他汀类药物可以降低脑梗死患者血清CRP水平，能在一定程度上改善预后。

Effects of statins on serum high sensitivity C - reactive protein and the prognosis of patients with cerebral infarction

Objective To study the relationship between serum high sensitivity C- reactive protein （ hs - CRP） and neurological functional deficit scales after cerebal infarction so as to evaluate effect of statins on hs- CRP levels and prognosis . Methods Forty cerebral infarction patients were divided by random , doubl - blind and placebo contrasstive methods into the control group and statins group （40 mg/d of simvastatin for 2 weeks ） . The serum levels of hs - CRP were detected before and after treatment. The neurological functional deficit scales of all patients were examined. Results The tevds of serum hs - CRP and the neurological functional deficit scales in statins group decreased significantly compared with control group （ P 〈0.05） . Conclusions The levels of serum hs- CRP are associated with prognosis of cerebral infarction, statins can reduce levels of serum hs - CRP so as to improve prognosis.