IgG neuropathy: an immunoelectron microscopic study |
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Authors: | Vallat Jean-Michel Magy Laurent Sindou Philippe Magdelaine Corinne Cros Didier |
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Institution: | Department of Neurology, University Hospital, 2 Avenue Martin Luther King, 87042 Limoges, France. vallat@unilim.fr |
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Abstract: | There are many potential mechanisms of peripheral nerve impairment by a monoclonal IgG dysglobulinemia. In this study, using electron microscopy, we observed widening of the myelin lamellae comparable to that commonly described in IgM neuropathies with antimyelin-associated glycoprotein activity. Such features have yet to be described in IgG neuropathies. In addition, we observed deposits of a granular material in the interstitial tissue of the nerve. By immunoelectron microscopy, we demonstrated the presence of the IgG in the lesions of myelin and the endoneurial space. A direct link between monoclonal dysglobulinemia (regardless of type) and polyneuropathy should be confirmed by nerve biopsy, because the result may influence treatment. |
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