风湿性心脏病二尖瓣置换术后左室形态及功能改变与心肌病变的关系

目的：探讨风湿性心脏病二尖瓣置换术后左室形态及功能改变与心肌病变的关系。方法：用彩色多普勒检测患术前及术后心功能并进行对比，同时用免疫组化法检测患心肌中增殖细胞核抗原（proliferating cell nuclear antigen,PCNA)表达量，并钭其与患术前心功能进行对比分析。结果：心肌病变较轻，行二尖瓣置换术后，心功能得到明显改善。心肌本身病变较重，行二尖瓣置换后，心功能未见明显改善，甚至下降或近期死亡。结论：风湿性心脏病二尖瓣置换术后，左室形态及功能因民病变的不同而得到不同程度的改善。风湿性心脏病的心肌病理改变是影响二尖瓣置换术后心功能的主要因素。

Relationship between change of morphosis and function of left ventricle and pathologic changes of myocardium after mitral valve replacement with rheumatic heart disease

AIM: This study aims to investigate the rel at ionship between the morphosis and function of left ventricle and the pathologic changes of myocardium following mitral valve replacement in patients with the rh eumatic heart disease. METHODS: Heart functions before a nd after operation were measured with the echocardiography. The expression of pr oliferating cell nuclear antigen (PCNA) was measured by immunohischemical staini ng .The results were analyzed to see if there is a correlation between the morph osis and function of left ventricle and the pathologic changes of myocardium. RESULTS: The expression of PCNA in the myocardium of patie nts with rheumatic heart diseases was significantly higher than that of healthy adult control group and was positively correlated with the cardiac function. CONCLUSION: The myocardium fibrosis in the myocardium of rh eumatic heart diseases is an important factor that exerts an effect on the cardi ac function after mitral valve replacement.