Expression of RAB27B is up-regulated in senescent human cells |
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| Authors: | Fujii Michihiko Kawai Yoshinori Endoh Morio Hossain Mohammad Nazir Nakabayashi Kazuhiko Ayusawa Dai |
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| Institution: | Division of Biochemistry, Kihara Institute for Biological Research and Graduate School of Integrated Science, Yokohama City University, Maioka-cho 641-12, Totsuka-ku, Yokohama 244-0813, Japan. |
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| Abstract: | Immortal SVts8 cells that express thermolabile SV40 T antigen exhibit a senescence-like phenomenon upon inactivation of the T antigen. By using a cDNA subtractive hybridization technique, RAB27B, a member of the RAB GTPase family, was found to be up-regulated in senescent SVts8 cells. The up-regulation of RAB27B depends on the p53 gene. Enhanced expression was also observed in replicative senescence in normal human fibroblasts. |
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| Keywords: | SV40 simian virus 40 |
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