IL-12 gene therapy for cancer: in synergy with other immunotherapies |
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| Authors: | Melero I Mazzolini G Narvaiza I Qian C Chen L Prieto J |
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| Affiliation: | 1. The Gene Therapy Division, Dept of Medicine, University of Navarra, C/Irunlarrea 1, 31008 Pamplona, Spain;2. Dept of Immunology, Mayo Clinic, Rochester, MN 55905, USA;1. Department of Psychiatry and Behavioral Sciences, NorthShore University HealthSystem, Evanston, Illinois;2. Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio;3. Department of Psychiatry and Psychology, Cleveland Clinic, Cleveland, Ohio;4. Kaufman Center for Heart Failure, Cleveland Clinic, Cleveland, Ohio;5. Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio;6. Center for Connected Care, Cleveland Clinic, Cleveland, Ohio;1. School of Medical and Molecular Biosciences, University of Technology Sydney, Ultimo, NSW 2007, Australia;2. Centre for Health Technologies, University of Technology Sydney, Ultimo, NSW 2007, Australia;3. The iThree Institute, University of Technology Sydney, Ultimo, NSW 2007, Australia;4. Centre for Biomedical Research, Burnet Institute, Melbourne, VIC 3004, Australia;5. Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia;6. St Vincent’s Clinical School, Faculty of Medicine, University of NSW, Darlinghurst, NSW 2010, Australia;1. Emergency Department, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, UK;2. Glasgow Forensic Mental Health Services, Douglas Inch Centre, 2 Woodside Terrace, Glasgow G3 7UY, UK |
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| Abstract: | In preclinical models of cancer, gene therapy with interleukin 12 (IL-12) has reached unprecedented levels of success when combined with immunotherapy approaches such as gene transfer of other cytokines and/or chemokines, costimulatory molecules or adoptive cell therapy. These combinations have been found to produce synergistic rather than additive effects. Meanwhile, IL-12 gene therapy is beginning clinical testing as a single agent, but combination strategies are at hand. |
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