乳腺癌X线钙化征象与ER、PR、CerbB-2表达的相关性研究

目的:探讨乳腺癌X线摄影钙化征象与雌激素受体(ER)、孕激素受体(PR)及人表皮生长因子相关基因(CerbB-2/HER-2/neu)表达的相关性。方法:回顾性分析87例术后病理诊断为乳腺癌患者的双乳腺X线轴位、斜位片,记录乳腺癌钙化情况,术后标本行免疫组织化学染色测定肿瘤细胞ER、PR及CerbB-2表达情况,分析乳腺癌钙化灶与上述因素的关系。结果:乳腺癌钙化灶与ER、PR表达无相关性,而乳腺癌钙化灶与CerbB-2的表达有相关性。结论:乳腺癌钙化征象与分子生物学指标CerbB-2之间存在一定的相关性。乳腺癌X线摄影从一定程度上反映了癌细胞的生物学行为和预后,为临床治疗方案的选择提供客观依据。

Correlative Study on the Relationship between the Calcification and the Expression of ER, PR and CerbB- in Breast Cancer

Objective:To evaluate the relationship between the malignant calcification and the expression of ER,PR and CerbB-2 in breast cancer.Methods:Mammography was performed in 87 cases of patients with breast cancer.Mammographic calcification of breast cancer were retrospectively studied.ER,PR and CerbB-2 expression of the specimens of the patients were examined with immunohistochemistry.The relationship between the malignant calcification and the expression of ER,PR and CerbB-2 was analyzed. Results:Positive expression of ER and PR was not significantly correlated with the malignant calcification of breast cancer,while the expression level of CerbB-2 was negatively correlated with the findings of calcification in breast cancer.Conclusion:There was a considerable extent of correlationship between the malignant calcification and the expression of CerbB-2 in breast cancer.Mammographic calcification of breast cancer not only reflected the tumor biological behavior and prognosis,but also provided information for clinical treatment planning of the relative cases as well.