| Effects of connective tissue growth factor and collagen type I scleroderma |
| |
| 引用本文： | Xiaoning Yan Jie Feng Bingjun Shi. Effects of connective tissue growth factor and collagen type I scleroderma[J]. 南京医科大学学报(英文版), 2007, 21(3): 175-179. DOI: 10.1016/S1007-4376(07)60041-0 |
| |
| 作者姓名： | Xiaoning Yan Jie Feng Bingjun Shi |
| |
| 作者单位： | Department of Dermatology, the Second Affiliated Hospital of Xi＇an Jiaotong University, Xi＇an 710004, China |
| |
| 摘 要： | Objective： To investigate the effects of connective tissue growth factor（CTGF） and collagen type I（COL-I） on the pathogenesis of scleroderma and explore the relationship between the level of COL-I and CTGF. Methods： 12 mice model of scleroderma was established by the injection of Bleomycin. The level of CTGF and COL-I were detected by immunohistochemical method. The relationship was analyzed between CTGF and COL-I level. As control group, 12 healthy mice were selected. Results： The levels of CTGF and COL-I in sclerotic models were higher than in normal controls （P 〈 0.05）. It was found that there was a correlation between the level of CTGF and COL-I. Conclusion： CTGF and COL-I played an important role in the hardening process of the skin lesions of the mice model, which may be involved in the pathogenesis of scleroderma.
|
| 关 键 词： | 结缔组织生长因子 CTGF 胶原I COL-I 硬皮病 |
| 收稿时间： | 2006-11-06 |
Effects of connective tissue growth factor and collagen type I scleroderma |
| |
| Xiaoning Yan,Jie Feng,Bingjun Shi,. Effects of connective tissue growth factor and collagen type I scleroderma[J]. Journal of Nanjing Medical University, 2007, 21(3): 175-179. DOI: 10.1016/S1007-4376(07)60041-0 |
| |
| Authors: | Xiaoning Yan Jie Feng Bingjun Shi |
| |
| Affiliation: | Department of Dermatology, The Second Affiliated Hospital of Xi'' an Jiaotong University, Xi'' an 710004, China |
| |
| Abstract: | ObjectiveTo investigate the effects of connective tissue growth factor (CTGF) and collagen type I (COL-l) on the pathogenesis of scleroderma and explore the relationship between the level of COL-I and CTGF.Methods12 mice model of scleroderma was established by the injection of Bleomycin. The level of CTGF and COL-I were detected by immunohistochemical method. The relationship was analyzed between CTGF and COL-I level. As control group, 12 healthy mice were selected.ResultsThe levels of CTGF and COL-I in sclerotic models were higher than in normal controls (P < 0.05). It was found that there was a correlation between the level of CTGF and COL-I.ConclusionCTGF and COL-I played an important role in the hardening process of the skin lesions of the mice model, which may be involved in the pathogenesis of scleroderma. |
| |
| Keywords: | connective tissue growth factor collagen type I scleroderma |
| 本文献已被 维普 ScienceDirect 等数据库收录！ |
