Synthesis and potential antimycotic activity of 4-substituted-3-(thiophene-2-yl-methyl)-Delta2-1,2,4-triazoline-5-thiones |
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| Authors: | Wujec Monika Pitucha Monika Dobosz Maria Kosikowska Urszula Malm Anna |
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| Affiliation: | Department of Organic Chemistry, Faculty of Pharmacy, Medical University Lublin, Poland. |
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| Abstract: | In the reaction of hydrazide of thiophene-2-acetic acid (1) with isothiocyanates, the respective thiosemicarbazides 2a-g were obtained. Further cyclization with 2% NaOH led to formation of 4-substituted-3-(thiophene- 2-yl-methyl)-Delta2-1,2,4-triazoline-5-thiones (3a-g). These compounds showed promising antimycotic activity. |
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