Tumor-specific transplantation antigen is expressed during SV40 lytic infection with wild-type and tsA mutant viruses. |
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| Authors: | J L Anderson R G Martin C Chang P T Mora |
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| Affiliation: | 1. Laboratory of Molecular Biology, National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, Maryland, USA;2. Macromolecular Biology Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, USA |
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| Abstract: | The expression of SV40 tumor-specific transplantation antigen (TSTA) in SV40-infected monkey cells has been assayed using detergent extracts of cell membranes and cytosol to immunize mice prior to an SV40 ascites-tumor challenge. TSTA is expressed during infection of CV-1 cells by wild-type SV40 and by a temperature-sensitive A mutant. Following infection by the tsA mutant, TSTA [like the tumor antigen (TA) but unlike viral DNA, capsid proteins, and mature virus] appears both at restrictive (40.5°) as well as at permissive (33°) temperatures. Kinetic studies show that the initial appearance of TSTA and TA is concurrent. |
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| Keywords: | Author to whom requests for reprints should be addressed. |
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