| 5-羟色胺转运体与肠易激综合征 |
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| 引用本文： | 张晓敏,林志辉. 5-羟色胺转运体与肠易激综合征[J]. 国际消化病杂志, 2006, 26(3): 172-174 |
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| 作者姓名： | 张晓敏 林志辉 |
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| 作者单位： | 福建医科大学省立临床学院胃肠病研究所,350001 |
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| 摘 要： | 肠易激综合征(IBS)是临床最常见的功能性肠病,病因尚不清楚。5-羟色胺(5-HT)是脑-肠轴中的关键递质,它在胃肠运动和感觉,以及中枢情感调节中有重要意义。5-羟色胺转运体(SERT)是一种对5-HT有高度亲和力的跨膜转运蛋白,可将效应部位的5-HT迅速再摄取。大量的证据表明,SERT在IBS的发生和发展中发挥重要的作用。
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| 关 键 词： | 5-羟色胺转运体 肠易激综合征 5-羟色胺 调控 基因多态性 |
| 收稿时间： | 2005-08-29 |
| 修稿时间： | 2005-08-29 |
Serotonin transporter and irritable bowel syndrome |
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| ZHANG Xiao-min,LIN Zhi-hui. Serotonin transporter and irritable bowel syndrome[J]. International Journal of Digestive Disease, 2006, 26(3): 172-174 |
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| Authors: | ZHANG Xiao-min LIN Zhi-hui |
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| Abstract: | IBS is the most common functional bowel disease,Which etiopathogenisis is still unclear. As a critical transmitter in brain-gut axis,5-HT is significant for regulating gastrointestinal motility and sensibility .also for adjusting sentiment. SERT is a transmembrane transporter protein with high affinity to 5-HT ,It can reuptake 5-HT from effctive location . Much evidence suggests that SERT palys an important role in the genesis and development of IBS. |
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| Keywords: | Serotonin transporter Irritable bowel syndrome Serotonin Control Gene polymorphism |
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