CD81 inhibits the proliferation of astrocytes by inducing G0/G1 arrest in vitro |
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| Authors: | Junfang Ma Rengang Liu Huiming Peng Jieping Zhou Haipeng Li |
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| Affiliation: | 1. Department of Neurology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China
2. Department of Anatomy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | Astrocytes play a major role in the reactive processes in response to neuronal injuries in the brain.Excessive gliosis is detrimental and can contribute to neuronal damage.CD81(TAPA),a member of the tetraspanin family of proteins,is upregulated by astrocytes after traumatic injury to the rat central nervous system(CNS).To further understand the role of CD81 in the inhibition of astrocytes,we analyzed the effects of a CD81 antibody,on cultured rat astrocytes.The results indicated that the effect worked in a ... |
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| Keywords: | CD81 astrocytes proliferation inhibition cell cycle tetraspanins |
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