| GABABR1基因(G1465A)多态性与脑梗死继发癫痫关联研究 |
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| 引用本文： | 王利军,王建平,蒋超,王颖颖,吴川杰.GABABR1基因(G1465A)多态性与脑梗死继发癫痫关联研究[J].中风与神经疾病杂志,2012,29(6):527-529. |
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| 作者姓名： | 王利军 王建平 蒋超 王颖颖 吴川杰 |
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| 作者单位： | 1. 郑州大学第五附属医院神经内科,河南郑州,450052
2. 郑州大学第一附属医院神经内科,河南郑州,450052 |
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| 摘 要： | 目的 探讨γ-氨基丁酸B受体B1亚单位(gamma-aminobutyric acid B receptor 1,GABABR1)基因(G1465A)多态性与汉族脑梗死患者继发癫痫的相关性.方法 取脑梗死继发癫痫患者肘静脉血,柱层析法提取血细胞基因组DNA,用PCR-RFLP技术检测GABABR1基因G1465A多态基因型,并与脑梗死无癫痫组和正常对照组进行比较分析.结果 3组GABABR1基因G1465A多态基因型都显示为G/G型,未发现A/G和A/A型.结论 汉族人群GABABR1基因(G1465A)未显示多态性,可能不是脑梗死继发癫痫的易感因素.
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| 关 键 词： | GABABR1 基因多态性 脑梗死 癫痫 汉族 |
Association between the polymorphisms of GABABR1(G1465A) gene and epilepsy after cerebral infarction |
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| Institution: | WANG Li-jun,WANG Jian-ping,JIANG Chao,et al.(Department of Neurology,The Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China) |
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| Abstract: | Objective To investigate the relationship between the polymorphism of GABABR1(G1465A) gene and epilepsy after cerebral infarction in Han population.Methods EDTA-blood specimens were collected from test objects.DNA samples were extracted with column chromatography.The polymorphism of GABABR1(G1465A) gene was detected by PCR-RFLP technique.Then the polymorphism in patients with epilepsy after cerebral infarction was compared with cerebral infarction group without epilepsy and normal control group.Results Only genotype G/G was observed in the three group.We did not find genotype A/G and A/A in our study.Conclusion There may be no association between the polymorphism of GABABR1(G1465A) gene and epilepsy after cerebral infarction in Han population. |
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| Keywords: | GABABR1 Polymorphism Cerebral infarction Epilepsy Han population |
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