进展性脑梗死患者血浆中D-二聚体、纤维蛋白原和血清超敏C-反应蛋白的变化及相关分析

目的测定进展性脑梗死患者血浆中D-二聚体（D-D）、纤维蛋白原和超敏C-反应蛋白（hs-CRP）水平及探讨其临床相关性。方法选择2005年5月~2011年8月本院住院的进展性脑梗死患者及同期住院的非进展性脑梗死患者各50例,以同期健康体检者50例为对照组,分别测定各自血浆中D-D、纤维蛋白原和血清hs-CRP水平,并进行统计学分析。结果进展性脑梗死组患者的hs-CRP、纤维蛋白原和D-D的含量较非进展性脑梗死组患者明显升高（P〈0.01）;非进展性脑梗死组患者hs-CRP、纤维蛋白原和D-D的含量较对照组明显升高（P〈0.01）;进展性脑梗死组患者D-D升高阳性率比非进展性脑梗死组患者高（P〈0.01）;非进展性脑梗死组患者D-D升高阳性率比对照组高（P〈0.05）。结论测定脑梗死患者这3种指标有助于进展性脑梗死的预测及制定相应的干预措施。

Changes and correlation analysis of plasma D-dimer,fibrinogen and serum high sensitivity C-reactive protein in patients with progressive cerebral infarction

Objective To determine plasma D-dimer（D-D）,fibrinogen and high sensitivity C-reactive protein（hs-CRP） level in patients with progressive cerebral infarction（PCI） and explore their clinical relevance.Methods Fifty PCI patients and another 50 patients with non-PCI who were hospitalized in our study from May 2005 to August 2011 were included in the study.Meanwhile 50 healthy subjects who received medical check-ups at the same period in our hospital were selected as the control group.D-D,fibrinogen,hs-CRP levels were determined and analyzed statistically in all the patients and subjects.Results The levels of hs-CRP,fibrinogen and D-D were increased more significantly in the PCI group than in the NPCI group（P0.01）.Levels of Hs-CRP,fibrinogen and D-D were increased more significantly in the NPCI group than in the control group（P0.01）.The positivity rate of D-D was higher in the PCI group than in the NPCI group（P0.01） and higher in the NPIC group than in the control group（P0.05）.Conclusion The determination of these three indicators in patients with cerebral infarction helps in the prediction of PCI and development of appropriate interventions.