氯沙坦钾对原发性高血压合并高尿酸血症患者血尿酸代谢的影响

目的评价氯沙坦钾治疗原发性高血压合并高尿酸血症患者的临床疗效。方法随机选择原发性高血压合并高尿酸血症患者66例,给予氯沙坦钾50 mg/d为起始剂量,根据血压及血尿酸水平调整使用剂量,在治疗前1 d,治疗后6、12周分别测量血压及血尿酸水平,观察入组患者的血压、尿酸及不良反应情况。结果入选患者在治疗前后血压均下降平稳,达至治疗目标值,治疗6周后血尿酸有不同程度的降低,12周后血尿酸均降至正常范围。整个治疗过程中未出现干咳、低血压、电解质紊乱等不良反应,未发现肝肾功能损伤及糖脂代谢紊乱。结论氯沙坦钾治疗原发性高血压安全、有效,不良反应发生率低,更能有效降低血尿酸水平,有助于控制痛风发作。

Effect of losartan potassium on the metabolism of blood uric acid in essential hypertension patients complicated with hyperuricemia

Objective To evaluate the clinical efficacy of losartan potassium in essential hypertension patients complicated with hyperuricemia.Methods Sixty-six essential hypertension patients complicated with hyperuricemia were administered losartan 50 mg/d as an initial dose,and the dose was adjusted according to the level of blood pressure and uric acid.The blood pressure and blood uric acid level were measured one day before and 6 and 12 weeks after the treatment,and adverse effects were observed.Results Both systolic and diastolic blood pressures significantly decreased after the treatment.The serum uric acid level was decreased to various degrees after 6-week treatment and recovered to normal range after 12-week treatment.No side reactions were found during the whole treatment.Conclusion Losartan can control blood pressure and decrease uric acid level effectively and safely,thus being contributive to reduce gout attacks.