2型糖尿病患者血同型半胱氨酸与踝肱指数及微量尿白蛋白关系的研究

目的探讨2型糖尿病（T2DM）患者血同型半胱氨酸（Hcy）与踝肱指数（ABI）及微量尿白蛋白（U-mAlb）的相关性。方法将90例2型糖尿病病患者按照Hcy水平的不同分为两组：高Hcy组为血Hcy〉10.5μmol/L,低Hcy组为血Hcy≤10.5μmol/L,分别测定踝臂指数（ABI）、U-mAlb。结果高Hcy组ABI明显低于低Hcy组（P〈0.05）,Hcy与ABI呈显著负相关,而U-mAlb高于低Hcy组（P〈0.01）。结论高同型半胱氨酸血症与糖尿病患者血管病变关系密切。

Relationship of ankle-brachial index and urinary albumin excretion with homocysteine in patients with type 2 diabetes mellitus

Objective To investigate the relationship of ankle-brachial index（ABI） and urinary albumin（U-mAlb） with homocysteine（Hcy） in patients with type 2 diabetes mellitus（T2DM）.Methods A total of 90 type 2 diabetes mellitus patients were divided into high Hcy group（n=48,Hcy10.5 μmol/L） and low Hcy group（n=42,Hcy≤10.5 μmol/L） according to serum homocysteine.ABI and U-mAlb were examined at the same time.Results ABI in high Hcy group was significantly lower than the low Hcy group（P0.05）.Hcy and ABI were negatively correlated.On the contrary,U-mAlb was higher in high Hcy group than in low Hcy（P0.01）.Conclusion In type 2 diabetes mellitus patients,Hcy is closely related with diabetic microangiopathy and diabetic vascular disease.