阿托伐他汀对代谢综合征腹内脂肪及肾功能的影响观察

目的观察阿托伐他汀对代谢综合征（MS）患者腹内脂肪和肾功能的影响,分析其疗效及安全性。方法将48例MS患者随机分为2组,治疗组在严格控制血压、血糖的基础上给予阿托伐他汀治疗,对照组仅接受基础治疗,对比2组临床疗效。结果 2组治疗后血压、血糖均较治疗前明显降低;治疗组腹内脂肪厚度与尿微量白蛋白（MAU）均明显下降,体重无明显变化;对照组腹内脂肪厚度、尿微量白蛋白（MAU）与治疗前无明显差异,体重明显增加。治疗组总胆固醇（TC）与治疗前相比明显降低,高密度脂蛋白胆固醇（HDL-C）明显升高,对照组血脂指标与治疗前相比无统计学差异。结论阿托伐他汀治疗MS患者可以有效降低腹内脂肪厚度,调节血脂,保护肾功能,其作用机制与降低内脏脂肪厚度存在一定关系。

Influence of atorvastatin on intraabdominal fat and renal function in metabolic syndrome

Objective To explore the influence of atorvastatin on intraabdominal fat and renal function in metabolic syndrome（MS） and analyze the efficacy and safety.Methods Forty-eight MS patients were divided into two groups randomly.The treatment group received atorvastatin based on strict control of blood pressure and glucose,and the control group received basic treatment.The effects of atorvastatin were compared between the two groups.Results After treatment,the levels of blood pressure and glucose markedly decreased in the two groups.The levels of intraabdominal fat thickness and urinary microalbumin（uMA） in the treatment group decreased obviously,while the weight had no significant change.The levels of intraabdominal fat thickness and uMA had no significant change in the control group,while the weight increased obviously.After treatment,the levels of total cholesterol（TC） significantly decreased,while the high-density lipoproteins-cholesterol（HDL-C） increased significantly in the treatment group.The blood lipid level had no significant changes in the control group.Conclusion Atorvastatin can decrease intraabdominal fat thickness,regulate blood lipid,protect renal function in MS patients,and the mechanism is related to reduction of visceral fat.