| 产后抑郁动物模型及行为学评价方法研究进展 |
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| 引用本文： | 唐娅辉. 产后抑郁动物模型及行为学评价方法研究进展[J]. 实验动物与比较医学, 2018, 26(1): 133-138 |
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| 作者姓名： | 唐娅辉 |
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| 作者单位： | 1. 湖南省中药粉体与创新药物省部共建国家重点实验室培育基地,长沙 410208; 2. 湖南省药物安全评价研究中心,新药药效与安全评价湖南省重点实验室,长沙 410331 |
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| 基金项目： | 湖湘青年创新人才基金(No. 2014) |
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| 摘 要： | 产后抑郁症(postpartum depression, PPD)是产褥期精神综合征中最常见的一种类型?由于PPD 疾病的复杂多变以及产妇分娩后所处的特殊时期,使得临床上研究该疾病存在很多局限性?因此,制备与建立临床接近PPD 动物模型及行为学评价方法对研究其发病机制具有重要作用?本综述主要介绍了常用的产后抑郁症动物模型以及行为学评价方法,为深入研究PPD 发病机制及药物开发提供实验方法?
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| 关 键 词： | 产后抑郁症 行为学 评价方法 |
| 收稿时间： | 2017-05-18 |
Research progress on animal models of postpartum depression and their behavior evaluation methods |
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| TANG Yahui. Research progress on animal models of postpartum depression and their behavior evaluation methods[J]. Laboratory Animal and Comparative Medicine, 2018, 26(1): 133-138 |
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| Authors: | TANG Yahui |
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| Affiliation: | 1.Key Laboratory of Traditional Chinese Medicine Power and Innovative Drugs of Hunan Province, Changsha 410208, China. 2.Hunan Center of Drug Safety Evaluation and Research of Drugs & Hunan Key Laboratory of Pharmacodynamics and Safety Evaluation of New Drugs, Changsha 410331 |
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| Abstract: | Postpartum depression (PPD) is one of the most common types of postpartum psychiatric syndromes. Because of the complex and changeable characteristics in PPD disease and the special period after childbirth, there are many clinical limitations in the study of this disease. Therefore, the preparation and establishment of a proper animal model closed to clinical and behavioral evaluation method plays an important role in study of its pathogenesis. This review mainly introduces the commonly used postpartum depression animal models and the behavioral evaluation method. It is hoped to provide a reference for further study of PPD pathogenesis and for the drug research and development. |
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| Keywords: | postpartum depression behavior evaluation methods |
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