A brief review of common mathematical calculations in therapeutic apheresis |
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Authors: | Elizabeth M. Staley San T. Hoang Hefei Liu Huy P. Pham |
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Affiliation: | 1. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri;2. Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California;3. Independent Researcher, Philadelphia, Pennsylvania;4. Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, California |
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Abstract: | Apheresis is defined as the removal of blood from the body, its separation into constituent components, and removal or manipulation of one of these components prior to intravascular return with or without the addition of replacement fluid. Patients undergoing therapeutic apheresis often have multiple comorbidities, potentially affecting their hemodynamic status. Thus, a thorough understanding of apheresis principles and calculations is required for the performance of safe, efficacious, and successful procedures. The performance of simple transfusions or red blood cell exchange procedures is additionally complicated by the difficulties inherent in the procurement of compatible blood products, and the emphasis on minimizing exposure to unnecessary blood products. It is essential that apheresis physicians be able to accurately evaluate the risks/benefits inherent in the procedural options and efficiently stratify patients to the optimal therapeutic modality. The formulas requisite for performing therapeutic apheresis calculations are herein reviewed. |
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Keywords: | apheresis calculations depletion exchange red blood cell transfusion replacement fluid simple transfusion |
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