Efficacy of linezolid in a staphylococcal endocarditis rabbit model |
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Authors: | Oramas-Shirey M P Buchanan L V Dileto-Fang C L Dailey C F Ford C W Batts D H Gibson J K |
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Institution: | Pharmacology 7250-209-205, 301 Henrietta Street, Pharmacia Corporation, Kalamazoo, MI 49001, USA. |
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Abstract: | A rabbit endocarditis model was used to test the efficacy of oral linezolid and iv vancomycin. Twenty-four hours after catheter placement across the aortic valve, rabbits were infected with 3.5 x 10(6) cfu of Staphylococcus aureus (UC-9258). Two days after infection, control rabbits were killed, and treated rabbits were given 5 days of therapy with linezolid at 8 h intervals (tds) using either 25, 50 or 75 mg/kg/dose, or vancomycin at 12 h intervals (bd) using 25 mg/kg/dose. Linezolid at 75 and 50 mg/kg, and vancomycin significantly reduced S. aureus in aortic valve vegetations compared with the control. Linezolid at 25 mg/kg was ineffective. The efficacy of 75 and 50 mg/kg linezolid was related to maintenance of plasma drug levels near or above the linezolid MIC for UC-9258 (2 mg/L). |
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