血清降钙素原动态监测在肺炎严重程度评估和预后判断中的应用价值

目的探讨社区获得性肺炎（CAP）住院患者血清降钙素原（PCT）动态监测在评估肺炎严重程度和预后判断中的应用价值。方法对某社区的100倒CAP患者的临床资料进行回顾性分析，并于入院次日清晨抽取外周静脉血，采用酶联免疫吸附试验（ELLSA）对患者血清中的PCT水平进行测定、分析，将其按照严重程度分为三组，即普通CAP组（49例）、重症cAP组（39例）及死亡CAP组（12例），比较三组基线资料、血PCT浓度及简化肺炎预后评分系统（PORT）分层与PCT水平的相关性。结果（1）三组患者中，平均年龄、简化PORT评分、平均住院时间、静脉抗菌药物使用时间、住院费用等方面的差异均具有统计学意义（P〈0．05）；（2）三组血清PCT水平从低到高依次为：普通cAP组、重症cAP组、死亡CAP组，且两两比较差异具有统计学意义（P〈o．05）；（3）血清PCT水平与PORT分层的相关系数为0．929（Pd0．05）。结论CAP住院患者血清PCT动态监测在评估肺炎严重程度和预后判断中具有较大的价值，能够提高患者的临床诊断准确度，有助于及时地采取有效的治疗措施。

Application value of changes of blood clearance of procalcitonin dynamic in hospitalized patients with community-ac-quired pneumonia in the assessment of pneumonia severity and prognosis

Objective To explore the application value of dynamic changes of blood clearance of procalcitonin （PCT） in hospitalized patients with community-acquired pneumonia（CAP） in the assessment of pneumonia severity and prognosis. Methods 100 cases of community patients with CAP in our hospital were retrospectively analyzed, and peripheral venous blood was extracted on the next morning, and serum PCT levels were measured by ELISA. The patients were randomly divided into three groups according to severity namely ordinary CAP group（n= 49）, severe CAP group （n ： 39） and dead group （n ： 12 ）. Baseline data, serum PCT concentrations, and Pneumonia Prognostic Scoring System（PORT） layered PCT levels were compared. Results （1） There were statistically significant differ- ences of the mean age, simplifying PORT, the average number of clays of hospitalization, intravenous antibiotics, hos- pitalization costs and other aspects among the three groups of patients（P~0.05）. （2） Serum PCT value~ ordinary CAP group~ severe CAP group~ dead group,and there was a statistical difference between any of the three groups （P〈0.05）. （3） Correlation coefficient of serum PCT levels and PORT layer was 0. 929（P〈0.05）. Conclusion The dynamic changes of blood clearance of procalcitonin in hospitalized patients with community-acquired pneumonia has large value in the assessment of pneumonia severity and prognosis,and it could improve the patientrs clinical diagnos- tic accuracy,and offer timely and effective treatment measures.