丙丁酚可干预小鼠动脉粥样硬化病变并调节B类I型清道夫受体的表达

目的研究丙丁酚对高脂高胆固醇饲养的载脂蛋白E基因敲除小鼠和C57BL6／J小鼠血脂及动脉粥样硬化病变的影响，以及肝脏B类Ⅰ型清道夫受体和PPARγ表达的变化。方法分别随机将20只载脂蛋白E^-/^-小鼠和20只C57BL6／J小鼠分为载脂蛋白E^-／^-高脂组和载脂蛋白E^-/^-高脂＋0．5％丙丁酚组。

The Dynamic Changes of Serum Von Willebrand Factor and High Sensitivity C-Reactive Protein in Renovascular Hypertensive Rats

Aim To study dynamic changes of serum von Willebrand factor(vWF) and high sensitivity C-reactive protein(hs-CRP) in renovascular hypertensive rats,and to investigate the effect of vWF and hs-CRP in the deployment of atherosclerosis(As) and stroke. Methods vWF and hs-CRP were measured with enzyme linked immunoabsorbent assay(ELISA),the results were compared with the control group and sham-opetated group. Results At the end of 4,8,12 weeks after the operation,the concenrations of serum vWF and hs-CRP were significantly increased compared with the control group and sham-operated group;the blood pressure were increasing in the hypertensive group after the operation,and the concenrations of serum vWF and hs-CRP were increasing simultaneously. Conclusion When the blood pressure were increasing,the concenrations of serum vWF and hs-CRP were increasing simultaneously;vWF and hs-CRP played vital roles in As.The high concenrations of serum vWF and hs-CRP might be the risk factors to ischemic stroke.